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C7DTX2

- C7DTX2_HUMAN

UniProt

C7DTX2 - C7DTX2_HUMAN

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Protein
Submitted name:

Steroid 21-hydroxylase

Gene

CYP21A2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Steroid 21-hydroxylaseImported
Gene namesi
Name:CYP21A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7DTX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL
60 70 80 90 100
GLTQKFGPIY RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL
110 120 130 140 150
VSXNYPDLSL GDYSLLWKAH KKLTRSALLL GIRDSMEPVV EQLTQEFCER
160 170 180 190 200
MRAQPGTPVA IEEEFSLLTC SIICYLTFGD KIKDDNLMPA YYKCIQEVLK
210 220 230 240 250
TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IXKRDHIVEM QLRQHKESLV
260 270 280 290 300
AGQWRDMMDY MLQGVAQPTM EEGSGQLLEG HVHMAAVDLL IGGTETTANT
310 320 330 340 350
LSWAVVFLLH HPEIQQRLQE XLXHELGPGA SSSRVPYKXR ARXPLLNAXX
360 370 380 390 400
XXXXXXXXXX XXXXXXXXXX XXSISGYXIP EGTVIIPNLQ GAHLDETVWE
410 420 430 440 450
RPHEFWPDRF LEPGKNSRAL AFGCGARVCL GEPLARLELF VVLTRLLQAF
460 470 480 490
TLLPSGDALP SLQPLPHCSV ILKMQPFQVR LQPRGMGAHS PGQSQ
Length:495
Mass (Da):55,919
Last modified:September 22, 2009 - v1
Checksum:i1EEB3C3A8051B7DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ222298 Genomic DNA. Translation: ACT35424.1.
UniGeneiHs.654479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ222298 Genomic DNA. Translation: ACT35424.1 .
UniGenei Hs.654479.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35483456.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Linkage analysis of the C4A/C4B copy number variation and polymorphisms of the adjacent steroid 21-hydroxylase gene in a healthy population."
    Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A.
    Mol. Immunol. 46:2623-2629(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M., Rajczy K., Fust G., Szilagyi A.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC7DTX2_HUMAN
AccessioniPrimary (citable) accession number: C7DTX2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.