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Protein

Kappa-conotoxin-like Em11.8

Gene
N/A
Organism
Conus emaciatus (False virgin cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like Em11.8
OrganismiConus emaciatus (False virgin cone)
Taxonomic identifieri89442 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000039204927 – 59Kappa-conotoxin-like Em11.8Add BLAST33
PropeptideiPRO_000039205063 – 67By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 43By similarity
Disulfide bondi36 ↔ 48By similarity
Disulfide bondi42 ↔ 51By similarity
Disulfide bondi47 ↔ 55By similarity
Modified residuei59Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR020242. Conotoxin_I2-superfamily.
PfamiView protein in Pfam
PF17557. Conotoxin_I2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162. Conotoxin_I2-superfamily. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7DQB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCGT
60
CRNVCHLRFG KRATFQE
Length:67
Mass (Da):7,633
Last modified:September 22, 2009 - v1
Checksum:i4A941D012446F62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ180865 mRNA. Translation: ACU30727.1.

Similar proteinsi

Entry informationi

Entry nameiCI2B8_CONEM
AccessioniPrimary (citable) accession number: C7DQB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: September 22, 2009
Last modified: November 22, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families