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Protein

UDP-glucose 6-dehydrogenase

Gene

ugdH

Organism
Methylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylobacterium dichloromethanicum (strain DM4))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30NADUniRule annotation1
Binding sitei35NADUniRule annotation1
Binding sitei86NADUniRule annotation1
Binding sitei122NAD; via amide nitrogenUniRule annotation1
Binding sitei155NADUniRule annotation1
Active sitei263NucleophileUniRule annotation1
Binding sitei266NADUniRule annotation1
Binding sitei331NADUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
Name:ugdHImported
ORF Names:METD_I3800Imported
OrganismiMethylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylobacterium dichloromethanicum (strain DM4))Imported
Taxonomic identifieri661410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008070 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC7CB26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 418UDPG_MGDP_dh_CInterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000153773
KOiK00012
OMAiLCTEWDE
OrthoDBiPOG091H05IK

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

C7CB26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAMIGSGY VGLVSGACLA DFGHEVVCID KDPGKIAALN EGRMPIYEPG
60 70 80 90 100
LDTLVAENVR AKRLSFSTDL KPAVAQAQAV FIAVGTPSRR GDGFADLSYV
110 120 130 140 150
YAAAREIAEA LTGYTVVVTK STVPVGTGDE VERIIREARP DIDVGIASNP
160 170 180 190 200
EFLREGAAIG DFKRPDRIVI GAEDNRAAAV MQEVYRPLYL NQAPILFTGR
210 220 230 240 250
RTAELTKYAA NAFLATKITF INEIADLCEQ VGANVQEVAR GIGLDNRIGG
260 270 280 290 300
KFLHAGPGYG GSCFPKDTLA LVKTAQDYGT PVRIVETVVA VNDQRKRAMA
310 320 330 340 350
RKVIAACGGS VRGKRVALLG LTFKPNTDDM RDAPSLSIIA GLQDAGAQIV
360 370 380 390 400
AYDPEGMEQA RPLLQGVAYA EDAYACAEGA DALVIVTEWN AFRALDLARL
410 420 430
KGLMRAPVLV DLRNVYAPEE ARRQGLRHVG VGALARYD
Length:438
Mass (Da):46,868
Last modified:September 22, 2009 - v1
Checksum:i7021CD47358A6CB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA Translation: CAX25438.1
RefSeqiWP_015823287.1, NC_012988.1

Genome annotation databases

EnsemblBacteriaiCAX25438; CAX25438; METDI3800
KEGGimdi:METDI3800

Similar proteinsi

Entry informationi

Entry nameiC7CB26_METED
AccessioniPrimary (citable) accession number: C7CB26
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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