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C7CAS3 (C7CAS3_METED) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218 SAAS SAAS005765

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218 SAAS SAAS005765

Cofactor

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity. HAMAP-Rule MF_01218 SAAS SAAS005765

Enzyme regulation

Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218 SAAS SAAS005765

Sequence similarities

Belongs to the UPRTase family. HAMAP-Rule MF_01218

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region138 – 14695-phospho-alpha-D-ribose 1-diphosphate binding By similarity HAMAP-Rule MF_01218
Region206 – 2083Uracil binding By similarity HAMAP-Rule MF_01218

Sites

Binding site8615-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218
Binding site11115-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218
Binding site2011Uracil; via amide nitrogen By similarity HAMAP-Rule MF_01218
Binding site20715-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218

Sequences

Sequence LengthMass (Da)Tools
C7CAS3 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 6E2339F15F4FEE30

FASTA21623,513
        10         20         30         40         50         60 
MQAESGGAAR VTVVDHPLVQ HKLTMMRDSD RSTKGFRELL NEIGMLLAYE VTRDLPLEPV 

        70         80         90        100        110        120 
TIQTPIQPME GRRIAGKKLV LAPILRAGVG FLDGMLSLMP SARVAHVGLY RDPDTLQAVE 

       130        140        150        160        170        180 
YYFKSPSDLA DRTVLVLDPM LATANSAVAA VERLKSRGAK DLRFVCLLAA PEGIARFQAA 

       190        200        210 
HPDVPVWTAA IDSHLNDHGY IVPGLGDAGD RMYGTR

« Hide

References

[1]"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources."
Vuilleumier S., Chistoserdova L., Lee M.C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. expand/collapse author list , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E.
PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 5838 / DM4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FP103042 Genomic DNA. Translation: CAX23814.1.
RefSeqYP_003067763.1. NC_012988.1.

3D structure databases

ProteinModelPortalC7CAS3.
SMRC7CAS3. Positions 10-216.
ModBaseSearch...

Protein-protein interaction databases

STRING661410.METDI2213.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAX23814; CAX23814; METDI2213.
GeneID8192266.
KEGGmdi:METDI2213.
PATRIC22523033. VBIMetExt143287_2050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0035.
HOGENOMHOG000262754.
KOK00761.
OMAYEVTRDM.
ProtClustDBCLSK970816.

Enzyme and pathway databases

BioCycMEXT661410:GJA1-2161-MONOMER.
UniPathwayUPA00574; UER00636.

Family and domain databases

HAMAPMF_01218_B. Upp_B.
InterProIPR000836. PRibTrfase_dom.
IPR005765. Ura_phspho_trans.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01091. upp. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7CAS3_METED
AccessionPrimary (citable) accession number: C7CAS3
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info