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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Methylobacterium extorquens (strain DSM 5838 / DM4) (Methylobacterium dichloromethanicum (strain DM4))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131SubstrateUniRule annotation
Binding sitei15 – 151SubstrateUniRule annotation
Active sitei100 – 1001ElectrophileUniRule annotation
Active sitei170 – 1701Proton acceptorUniRule annotation

GO - Molecular functioni

  1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
  3. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation, Pentose shuntUniRule annotation

Enzyme and pathway databases

BioCyciMEXT661410:GJA1-5625-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotationImported
Ordered Locus Names:METDI5716Imported
OrganismiMethylobacterium extorquens (strain DSM 5838 / DM4) (Methylobacterium dichloromethanicum (strain DM4))Imported
Taxonomic identifieri661410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008070: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi661410.METDI5716.

Structurei

3D structure databases

ProteinModelPortaliC7C913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0149.
HOGENOMiHOG000226414.
KOiK01803.
OMAiEANRICG.
OrthoDBiEOG66QM23.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7C913-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEGRRPLV AGNWKMNGLL SSVPTVEAIR DGLSPALADK IDVLICPPAT
60 70 80 90 100
LISSCVAAVY GSVVAIGGQN LHARPSGAFT GSISAEMFAD LGATYVIVGH
110 120 130 140 150
SERRAYHYET DDGVHAKALG ARRAGLRGII CVGETMEERQ QGRALDIVRA
160 170 180 190 200
QLAIGLPKGA TGADTVIAYE PVWAIGSGRT PTATEIAEVH ASLREMLDKL
210 220 230 240 250
VGEEAHKIRI LYGGSVKPSN ARELMAVENV DGALVGGASL VAEDFLGICR

AYEG
Length:254
Mass (Da):26,563
Last modified:September 22, 2009 - v1
Checksum:i0F35FB416B7D4E0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA. Translation: CAX27320.1.
RefSeqiYP_003071125.1. NC_012988.1.

Genome annotation databases

EnsemblBacteriaiCAX27320; CAX27320; METDI5716.
GeneIDi8194883.
KEGGimdi:METDI5716.
PATRICi22529885. VBIMetExt143287_5445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA. Translation: CAX27320.1.
RefSeqiYP_003071125.1. NC_012988.1.

3D structure databases

ProteinModelPortaliC7C913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi661410.METDI5716.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAX27320; CAX27320; METDI5716.
GeneIDi8194883.
KEGGimdi:METDI5716.
PATRICi22529885. VBIMetExt143287_5445.

Phylogenomic databases

eggNOGiCOG0149.
HOGENOMiHOG000226414.
KOiK01803.
OMAiEANRICG.
OrthoDBiEOG66QM23.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.
BioCyciMEXT661410:GJA1-5625-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5838 / DM4Imported.

Entry informationi

Entry nameiC7C913_METED
AccessioniPrimary (citable) accession number: C7C913
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.