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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Methylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylobacterium dichloromethanicum (strain DM4))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotationSAAS annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100ElectrophileUniRule annotation1
Active sitei170Proton acceptorUniRule annotation1
Binding sitei176Substrate; via amide nitrogenUniRule annotation1
Binding sitei215SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotationSAAS annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotationSAAS annotation (EC:5.3.1.1UniRule annotationSAAS annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotationImported
Ordered Locus Names:METDI5716Imported
OrganismiMethylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylobacterium dichloromethanicum (strain DM4))Imported
Taxonomic identifieri661410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008070 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC7C913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 15Substrate bindingUniRule annotation3
Regioni236 – 237Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000226414
KOiK01803
OMAiLCVGEGL
OrthoDBiPOG091H02GL

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

C7C913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGRRPLV AGNWKMNGLL SSVPTVEAIR DGLSPALADK IDVLICPPAT
60 70 80 90 100
LISSCVAAVY GSVVAIGGQN LHARPSGAFT GSISAEMFAD LGATYVIVGH
110 120 130 140 150
SERRAYHYET DDGVHAKALG ARRAGLRGII CVGETMEERQ QGRALDIVRA
160 170 180 190 200
QLAIGLPKGA TGADTVIAYE PVWAIGSGRT PTATEIAEVH ASLREMLDKL
210 220 230 240 250
VGEEAHKIRI LYGGSVKPSN ARELMAVENV DGALVGGASL VAEDFLGICR

AYEG
Length:254
Mass (Da):26,563
Last modified:September 22, 2009 - v1
Checksum:i0F35FB416B7D4E0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103042 Genomic DNA Translation: CAX27320.1
RefSeqiWP_003602146.1, NC_012988.1

Genome annotation databases

EnsemblBacteriaiCAX27320; CAX27320; METDI5716
KEGGimdi:METDI5716

Similar proteinsi

Entry informationi

Entry nameiC7C913_METED
AccessioniPrimary (citable) accession number: C7C913
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health