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C7C6X7

- C7C6X7_METED

UniProt

C7C6X7 - C7C6X7_METED

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Protein
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Gene
glnD, METDI0212
Organism
Methylobacterium extorquens (strain DSM 5838 / DM4) (Methylobacterium dichloromethanicum (strain DM4))
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism By similarity.UniRule annotation

Catalytic activityi

UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII].UniRule annotationSAAS annotations
Uridylyl-[protein-PII] + H2O = UMP + [protein-PII].UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity By similarity.UniRule annotation

GO - Molecular functioni

  1. [protein-PII] uridylyltransferase activity Source: UniProtKB-HAMAP
  2. amino acid binding Source: InterPro
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. regulation of nitrogen utilization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotations, NucleotidyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMEXT661410:GJA1-205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional uridylyltransferase/uridylyl-removing enzymeUniRule annotation
Short name:
UTase/URUniRule annotation
Alternative name(s):
Bifunctional [protein-PII] modification enzyme
Bifunctional nitrogen sensor protein
Gene namesi
Name:glnDUniRule annotationImported
Ordered Locus Names:METDI0212Imported
OrganismiMethylobacterium extorquens (strain DSM 5838 / DM4) (Methylobacterium dichloromethanicum (strain DM4))Imported
Taxonomic identifieri661410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008070: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi661410.METDI0212.

Structurei

3D structure databases

ProteinModelPortaliC7C6X7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini510 – 614105HD By similarityUniRule annotation
Add
BLAST
Domaini725 – 80278ACT 1 By similarityUniRule annotation
Add
BLAST
Domaini835 – 91884ACT 2 By similarityUniRule annotation
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 367367Uridylyltransferase By similarityUniRule annotation
Add
BLAST
Regioni369 – 724356Uridylyl-removing By similarityUniRule annotation
Add
BLAST

Domaini

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the GlnD family.UniRule annotation
Contains 1 HD domain.UniRule annotation
Contains 2 ACT domains.UniRule annotation
Contains ACT domains.SAAS annotations
Contains HD domain.SAAS annotations

Keywords - Domaini

RepeatUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG2844.
HOGENOMiHOG000261779.
KOiK00990.
OMAiLYCLWDM.
OrthoDBiEOG6CCH44.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_00277. PII_uridylyl_transf.
InterProiIPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF01842. ACT. 2 hits.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006288. PII_uridyltransf. 1 hit.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01693. UTase_glnD. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7C6X7-1 [UniParc]FASTAAdd to Basket

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MFDPVPVLEK IVASLDRDAR EPTKLRGLLV PELRKVIETG HAEAERLLLK    50
ERDGLACAQR LSRLTDAVVR AIYDAVVWRL YPNDNPSTGE HLAIVATGGY 100
GRGTMAPGSD IDLLFLLPYK QTAWSESVVE AMLYVLWDLK LKVGHATRSV 150
EECLREGRAD MTIRTALLES RFLFGSRSLF EEMVTRFDTE LVIGSASEFV 200
DAKLRERDAR VAKAGASRYL VEPNVKDGKG GLRDLNTLFW IAKYTYRVRN 250
QAELVHAGLF TPDEYRLFER CEEFLWRVRC HIHFVTGRPE ERLSFGLQPK 300
IAERLGFGSR GGLSGVERFM KAYFLIAKDV GDLTAIVCAE LEARHAKRTP 350
VLDRWIGRFR DRFRATSIEA EDFWIDNGRV NIRGEDAFER DPVNLIRLFW 400
LADRHNLPIH PDAARLANRS LKLITHAVRI DPEANRLFLD ILTSKNAPET 450
ILRSMNEAGV LGRFIPEFGR IVAMMQFNMY HHYTVDEHLL RSLGVLAAID 500
SGRVRDEHPL ASRLIDTIHN RRALYVAILL HDIAKGRPED HSIAGAAIAR 550
KLGPRFGLSQ AETETVSWLV EHHLLMSMTA QSRDLSDRRT IEKFASEVQS 600
LERLKLLAIL TVADIKAVGP GVWTAWKGTL LRTLYDETEV VLSGGHSEIA 650
RTDRVRLIQM ALREQLSDWN SELFDGYAAR HNQAYWLKVD STRHFKNARF 700
LRTVMEEGRT SATTYETDPV RGVTELTVYS PDHPRLLAII TGACATMGGN 750
IVDAQIFTTT DGFALDSIFI SRAFERDEDE LRRAGRIATA IERALKGEIK 800
IAELVADKHP KQPPKTFLVP PDVSIDNALS SRETVVEITG LDRPGLLYEL 850
TTGLNRLSLN ITSAHVATFG ERAVDVFYVT DLTGTRVVQP DRLAMIRAAV 900
MEVFASDVAA LRAEGLDALV DSPPPREL 928
Length:928
Mass (Da):104,425
Last modified:September 22, 2009 - v1
Checksum:iD3C1E4F56083055A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP103042 Genomic DNA. Translation: CAX21881.1.
RefSeqiWP_012779027.1. NC_012988.1.
YP_003065946.1. NC_012988.1.

Genome annotation databases

EnsemblBacteriaiCAX21881; CAX21881; METDI0212.
GeneIDi8190687.
KEGGimdi:METDI0212.
PATRICi22519508. VBIMetExt143287_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP103042 Genomic DNA. Translation: CAX21881.1 .
RefSeqi WP_012779027.1. NC_012988.1.
YP_003065946.1. NC_012988.1.

3D structure databases

ProteinModelPortali C7C6X7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 661410.METDI0212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX21881 ; CAX21881 ; METDI0212 .
GeneIDi 8190687.
KEGGi mdi:METDI0212.
PATRICi 22519508. VBIMetExt143287_0329.

Phylogenomic databases

eggNOGi COG2844.
HOGENOMi HOG000261779.
KOi K00990.
OMAi LYCLWDM.
OrthoDBi EOG6CCH44.

Enzyme and pathway databases

BioCyci MEXT661410:GJA1-205-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_00277. PII_uridylyl_transf.
InterProi IPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view ]
Pfami PF01842. ACT. 2 hits.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006288. PII_uridyltransf. 1 hit.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01693. UTase_glnD. 1 hit.
PROSITEi PS51671. ACT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5838 / DM4.

Entry informationi

Entry nameiC7C6X7_METED
AccessioniPrimary (citable) accession number: C7C6X7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotations

External Data

Dasty 3

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