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C7C419 (C7C419_CANFA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1) EMBL CAZ17012.1
Gene names
Name:SERPINH1 EMBL CAZ17012.1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) EMBL CAZ17012.1
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Keywords
   Biological processStress response EMBL CAZ17012.1
   DomainCollagen EMBL CAZ17012.1
   Technical term3D-structure PDB 4AU2 PDB 4AU4 PDB 4AWR
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C7C419 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: E270A18B96E6E7FF

FASTA41846,611
        10         20         30         40         50         60 
MRFLLLLNTC CLLAVVLAAE VKKPAAAVAP GSAEKLSPKA ATLAERSAGL AFSLYQAMAK 

        70         80         90        100        110        120 
DQAVENILLS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN 

       130        140        150        160        170        180 
STARNVTWKL GSRLYGPSSV SFAEDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 

       190        200        210        220        230        240 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVTMMHRT 

       250        260        270        280        290        300 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 

       310        320        330        340        350        360 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFEWD 

       370        380        390        400        410 
TEGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

« Hide

References

[1]"A Missense Mutation in the SERPINH1 Gene in Dachshunds with Osteogenesis Imperfecta."
Drogemuller C., Becker D., Brunner A., Haase B., Kircher P., Seeliger F., Fehr M., Baumann U., Lindblad-Toh K., Leeb T.
PLoS Genet. 5:e1000579-e1000579(2009)
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition."
Widmer C., Gebauer J.M., Brunstein E., Rosenbaum S., Zaucke F., Drogemuller C., Leeb T., Baumann U.
Proc. Natl. Acad. Sci. U.S.A. 109:13243-13247(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 36-418.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN395288 mRNA. Translation: CAZ17012.1.
UniGeneCfa.6125.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AU2X-ray2.30A/B/C/D36-418[»]
4AU4X-ray2.97A/B/C/D/E/F/G36-418[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGC7C419.

Proteomic databases

PaxDbC7C419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG4826.

Family and domain databases

InterProIPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. Prot_inh_serpin. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7C419_CANFA
AccessionPrimary (citable) accession number: C7C419
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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