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C7C1C0

- C7C1C0_HELPB

UniProt

C7C1C0 - C7C1C0_HELPB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter pylori (strain B38)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei577 – 5771ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL592205:GJAG-1530-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:leuSUniRule annotationImported
    Ordered Locus Names:HELPY_1550Imported
    OrganismiHelicobacter pylori (strain B38)Imported
    Taxonomic identifieri592205 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000313: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi592205.HELPY_1550.

    Structurei

    3D structure databases

    ProteinModelPortaliC7C1C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi574 – 5785"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7C1C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDFINIIEK KWQEFWWKNK SFEPKDDFNL PKKYILSMLP YPSGEIHMGH    50
    VRNYTIGDAL ARYYRLHHYN VLHPMGFDSF GMPAENAAIK HGIHPKTWTY 100
    ENIEAMQKEF EALGFSFSKN REFATSDPDY TKFEQQFFID LWEKGLIYRK 150
    KAMLNWCPND KTVLANEQVI DGKCWRCDTE VVQKELYQYY LKITNYAEEL 200
    LKDLETLEDH WPSQVLIMQK NWIGKSSGLQ FGFKIADECL KACNNIQEIE 250
    VFTTRADTIY GVTYIAIAPE HPLVEHAIKQ VSQEDSKMIK AILNTTQRER 300
    ALEKKGAFLG IYAIHPLTKQ KIPVWVANFA LANYGSGALM GVPACDERDF 350
    EFANLYHIPI KVITQSPQNL PHTKEEVLKN SGEWSNLSSS VAREKIIAYF 400
    EKENLGKRVI NYRLQDWGVS RQRYWGAPIP MIHCKHCGIV PETQLPVTLP 450
    EDIVIDGEGN PLERHASWKF AQCPKCHKDA LRETDTMDTF IQSSWYFLRY 500
    TTPKNQRENQ AFDQNYLKYF MPVDTYIGGI EHAILHLLYA RFFTKALRDL 550
    GYLHLDEPFK QLITQGMVLK NGAKMSKSKG NVVSPKEILK KYGADAARLF 600
    ILFAAPPAKE LEWNDSALEG AHRFIKRLYD KASAITPTTS KPEFKGVSLN 650
    EAQKLGRKKV YEALKKSHEI FNKAESAYAF NTLIASCMEA LNALNAQTNE 700
    QILCEGYFVL LQILEPIIPH TAWELSERLF KRENFKPIAI DESALMEDFM 750
    TLGLTINGKR RAELKVNINA SKEEIIILAK KELEKYLEKA SVKKEIYVPN 800
    KLVNFVVA 808
    Length:808
    Mass (Da):93,254
    Last modified:September 22, 2009 - v1
    Checksum:i55221F7BDC90B27E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM991728 Genomic DNA. Translation: CAX30251.1.
    RefSeqiWP_015829051.1. NC_012973.1.
    YP_003058186.1. NC_012973.1.

    Genome annotation databases

    EnsemblBacteriaiCAX30251; CAX30251; HELPY_1550.
    GeneIDi8208297.
    KEGGihpb:HELPY_1550.
    PATRICi20597775. VBIHelPyl144313_1538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM991728 Genomic DNA. Translation: CAX30251.1 .
    RefSeqi WP_015829051.1. NC_012973.1.
    YP_003058186.1. NC_012973.1.

    3D structure databases

    ProteinModelPortali C7C1C0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 592205.HELPY_1550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAX30251 ; CAX30251 ; HELPY_1550 .
    GeneIDi 8208297.
    KEGGi hpb:HELPY_1550.
    PATRICi 20597775. VBIHelPyl144313_1538.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HPYL592205:GJAG-1530-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B38Imported.

    Entry informationi

    Entry nameiC7C1C0_HELPB
    AccessioniPrimary (citable) accession number: C7C1C0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3