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C7C1C0

- C7C1C0_HELPB

UniProt

C7C1C0 - C7C1C0_HELPB

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Protein
Leucine--tRNA ligase
Gene
leuS, HELPY_1550
Organism
Helicobacter pylori (strain B38)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL592205:GJAG-1530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase
Gene namesi
Name:leuSUniRule annotationImported
Ordered Locus Names:HELPY_1550Imported
OrganismiHelicobacter pylori (strain B38)Imported
Taxonomic identifieri592205 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000313: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi592205.HELPY_1550.

Structurei

3D structure databases

ProteinModelPortaliC7C1C0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi574 – 5785"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7C1C0-1 [UniParc]FASTAAdd to Basket

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MMDFINIIEK KWQEFWWKNK SFEPKDDFNL PKKYILSMLP YPSGEIHMGH    50
VRNYTIGDAL ARYYRLHHYN VLHPMGFDSF GMPAENAAIK HGIHPKTWTY 100
ENIEAMQKEF EALGFSFSKN REFATSDPDY TKFEQQFFID LWEKGLIYRK 150
KAMLNWCPND KTVLANEQVI DGKCWRCDTE VVQKELYQYY LKITNYAEEL 200
LKDLETLEDH WPSQVLIMQK NWIGKSSGLQ FGFKIADECL KACNNIQEIE 250
VFTTRADTIY GVTYIAIAPE HPLVEHAIKQ VSQEDSKMIK AILNTTQRER 300
ALEKKGAFLG IYAIHPLTKQ KIPVWVANFA LANYGSGALM GVPACDERDF 350
EFANLYHIPI KVITQSPQNL PHTKEEVLKN SGEWSNLSSS VAREKIIAYF 400
EKENLGKRVI NYRLQDWGVS RQRYWGAPIP MIHCKHCGIV PETQLPVTLP 450
EDIVIDGEGN PLERHASWKF AQCPKCHKDA LRETDTMDTF IQSSWYFLRY 500
TTPKNQRENQ AFDQNYLKYF MPVDTYIGGI EHAILHLLYA RFFTKALRDL 550
GYLHLDEPFK QLITQGMVLK NGAKMSKSKG NVVSPKEILK KYGADAARLF 600
ILFAAPPAKE LEWNDSALEG AHRFIKRLYD KASAITPTTS KPEFKGVSLN 650
EAQKLGRKKV YEALKKSHEI FNKAESAYAF NTLIASCMEA LNALNAQTNE 700
QILCEGYFVL LQILEPIIPH TAWELSERLF KRENFKPIAI DESALMEDFM 750
TLGLTINGKR RAELKVNINA SKEEIIILAK KELEKYLEKA SVKKEIYVPN 800
KLVNFVVA 808
Length:808
Mass (Da):93,254
Last modified:September 22, 2009 - v1
Checksum:i55221F7BDC90B27E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM991728 Genomic DNA. Translation: CAX30251.1.
RefSeqiWP_015829051.1. NC_012973.1.
YP_003058186.1. NC_012973.1.

Genome annotation databases

EnsemblBacteriaiCAX30251; CAX30251; HELPY_1550.
GeneIDi8208297.
KEGGihpb:HELPY_1550.
PATRICi20597775. VBIHelPyl144313_1538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM991728 Genomic DNA. Translation: CAX30251.1 .
RefSeqi WP_015829051.1. NC_012973.1.
YP_003058186.1. NC_012973.1.

3D structure databases

ProteinModelPortali C7C1C0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592205.HELPY_1550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX30251 ; CAX30251 ; HELPY_1550 .
GeneIDi 8208297.
KEGGi hpb:HELPY_1550.
PATRICi 20597775. VBIHelPyl144313_1538.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HPYL592205:GJAG-1530-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B38Imported.

Entry informationi

Entry nameiC7C1C0_HELPB
AccessioniPrimary (citable) accession number: C7C1C0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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