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C7C1C0

- C7C1C0_HELPB

UniProt

C7C1C0 - C7C1C0_HELPB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter pylori (strain B38)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL592205:GJAG-1530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
Ordered Locus Names:HELPY_1550Imported
OrganismiHelicobacter pylori (strain B38)Imported
Taxonomic identifieri592205 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000313: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi592205.HELPY_1550.

Structurei

3D structure databases

ProteinModelPortaliC7C1C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotationAdd
BLAST
Motifi574 – 5785"KMSKS" regionUniRule annotation

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7C1C0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDFINIIEK KWQEFWWKNK SFEPKDDFNL PKKYILSMLP YPSGEIHMGH
60 70 80 90 100
VRNYTIGDAL ARYYRLHHYN VLHPMGFDSF GMPAENAAIK HGIHPKTWTY
110 120 130 140 150
ENIEAMQKEF EALGFSFSKN REFATSDPDY TKFEQQFFID LWEKGLIYRK
160 170 180 190 200
KAMLNWCPND KTVLANEQVI DGKCWRCDTE VVQKELYQYY LKITNYAEEL
210 220 230 240 250
LKDLETLEDH WPSQVLIMQK NWIGKSSGLQ FGFKIADECL KACNNIQEIE
260 270 280 290 300
VFTTRADTIY GVTYIAIAPE HPLVEHAIKQ VSQEDSKMIK AILNTTQRER
310 320 330 340 350
ALEKKGAFLG IYAIHPLTKQ KIPVWVANFA LANYGSGALM GVPACDERDF
360 370 380 390 400
EFANLYHIPI KVITQSPQNL PHTKEEVLKN SGEWSNLSSS VAREKIIAYF
410 420 430 440 450
EKENLGKRVI NYRLQDWGVS RQRYWGAPIP MIHCKHCGIV PETQLPVTLP
460 470 480 490 500
EDIVIDGEGN PLERHASWKF AQCPKCHKDA LRETDTMDTF IQSSWYFLRY
510 520 530 540 550
TTPKNQRENQ AFDQNYLKYF MPVDTYIGGI EHAILHLLYA RFFTKALRDL
560 570 580 590 600
GYLHLDEPFK QLITQGMVLK NGAKMSKSKG NVVSPKEILK KYGADAARLF
610 620 630 640 650
ILFAAPPAKE LEWNDSALEG AHRFIKRLYD KASAITPTTS KPEFKGVSLN
660 670 680 690 700
EAQKLGRKKV YEALKKSHEI FNKAESAYAF NTLIASCMEA LNALNAQTNE
710 720 730 740 750
QILCEGYFVL LQILEPIIPH TAWELSERLF KRENFKPIAI DESALMEDFM
760 770 780 790 800
TLGLTINGKR RAELKVNINA SKEEIIILAK KELEKYLEKA SVKKEIYVPN

KLVNFVVA
Length:808
Mass (Da):93,254
Last modified:September 22, 2009 - v1
Checksum:i55221F7BDC90B27E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM991728 Genomic DNA. Translation: CAX30251.1.
RefSeqiYP_003058186.1. NC_012973.1.

Genome annotation databases

EnsemblBacteriaiCAX30251; CAX30251; HELPY_1550.
GeneIDi8208297.
KEGGihpb:HELPY_1550.
PATRICi20597775. VBIHelPyl144313_1538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM991728 Genomic DNA. Translation: CAX30251.1 .
RefSeqi YP_003058186.1. NC_012973.1.

3D structure databases

ProteinModelPortali C7C1C0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592205.HELPY_1550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX30251 ; CAX30251 ; HELPY_1550 .
GeneIDi 8208297.
KEGGi hpb:HELPY_1550.
PATRICi 20597775. VBIHelPyl144313_1538.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HPYL592205:GJAG-1530-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B38Imported.

Entry informationi

Entry nameiC7C1C0_HELPB
AccessioniPrimary (citable) accession number: C7C1C0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3