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C7BYY8

- C7BYY8_HELPB

UniProt

C7BYY8 - C7BYY8_HELPB

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Protein

Alanine racemase

Gene
alr, HELPY_0927
Organism
Helicobacter pylori (strain B38)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei135 – 1351Substrate By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPYL592205:GJAG-909-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HELPY_0927Imported
OrganismiHelicobacter pylori (strain B38)Imported
Taxonomic identifieri592205 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000313: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi592205.HELPY_0927.

Structurei

3D structure databases

ProteinModelPortaliC7BYY8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

C7BYY8-1 [UniParc]FASTAAdd to Basket

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MLKRASFVEV DTASLRHNFS AVKSIIPKDA CVMAVVKANA YGVGAIKASE    50
IFLQEGANYL GVAALDEALE LRSYFSKTPI LILGYSPNSN ASMLIDNDLS 100
AMVFSFEQAE VFSQMALKSQ KRLKVHLKID TGMHRLGLEP NFKSIEIIKK 150
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY 200
RHAYNSAGIL SLCNGNENRF LNLYRPGIML YGFYPSNEMK ESCPTILKNV 250
VSLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLVRALGN 300
RIQVAINNQL APLIGKVCMD QCFVKLNDIQ AKEGDEVILF GDKSTKANDA 350
SEIAVLLNTI PYETISTLSK RLERVYI 377
Length:377
Mass (Da):41,920
Last modified:September 22, 2009 - v1
Checksum:iC9C7127EE08697D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM991728 Genomic DNA. Translation: CAX29451.1.
RefSeqiYP_003057645.1. NC_012973.1.

Genome annotation databases

EnsemblBacteriaiCAX29451; CAX29451; HELPY_0927.
GeneIDi8207992.
KEGGihpb:HELPY_0927.
PATRICi20596506. VBIHelPyl144313_0928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM991728 Genomic DNA. Translation: CAX29451.1 .
RefSeqi YP_003057645.1. NC_012973.1.

3D structure databases

ProteinModelPortali C7BYY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592205.HELPY_0927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX29451 ; CAX29451 ; HELPY_0927 .
GeneIDi 8207992.
KEGGi hpb:HELPY_0927.
PATRICi 20596506. VBIHelPyl144313_0928.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi FIMSHLA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL592205:GJAG-909-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B38Imported.

Entry informationi

Entry nameiC7BYY8_HELPB
AccessioniPrimary (citable) accession number: C7BYY8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi