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Protein

Alanine racemase

Gene

alr

Organism
Helicobacter pylori (strain B38)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL592205:GJAG-909-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HELPY_0927Imported
OrganismiHelicobacter pylori (strain B38)Imported
Taxonomic identifieri592205 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000313 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi592205.HELPY_0927.

Structurei

3D structure databases

ProteinModelPortaliC7BYY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

C7BYY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRASFVEV DTASLRHNFS AVKSIIPKDA CVMAVVKANA YGVGAIKASE
60 70 80 90 100
IFLQEGANYL GVAALDEALE LRSYFSKTPI LILGYSPNSN ASMLIDNDLS
110 120 130 140 150
AMVFSFEQAE VFSQMALKSQ KRLKVHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRF LNLYRPGIML YGFYPSNEMK ESCPTILKNV
260 270 280 290 300
VSLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLVRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNDIQ AKEGDEVILF GDKSTKANDA
360 370
SEIAVLLNTI PYETISTLSK RLERVYI
Length:377
Mass (Da):41,920
Last modified:September 21, 2009 - v1
Checksum:iC9C7127EE08697D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM991728 Genomic DNA. Translation: CAX29451.1.
RefSeqiYP_003057645.1. NC_012973.1.

Genome annotation databases

EnsemblBacteriaiCAX29451; CAX29451; HELPY_0927.
KEGGihpb:HELPY_0927.
PATRICi20596506. VBIHelPyl144313_0928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM991728 Genomic DNA. Translation: CAX29451.1.
RefSeqiYP_003057645.1. NC_012973.1.

3D structure databases

ProteinModelPortaliC7BYY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi592205.HELPY_0927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAX29451; CAX29451; HELPY_0927.
KEGGihpb:HELPY_0927.
PATRICi20596506. VBIHelPyl144313_0928.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciHPYL592205:GJAG-909-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B38Imported.

Entry informationi

Entry nameiC7BYY8_HELPB
AccessioniPrimary (citable) accession number: C7BYY8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2009
Last sequence update: September 21, 2009
Last modified: March 31, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.