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C7BYR6 (C7BYR6_HELPB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP-Rule MF_00435
EC=1.1.1.86 HAMAP-Rule MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP-Rule MF_00435
Alpha-keto-beta-hydroxylacyl reductoisomerase HAMAP-Rule MF_00435
Gene names
Name:ilvC HAMAP-Rule MF_00435 EMBL CAX28877.1
Ordered Locus Names:HELPY_0334 EMBL CAX28877.1
OrganismHelicobacter pylori (strain B38) [Complete proteome] [HAMAP] EMBL CAX28877.1
Taxonomic identifier592205 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS000506

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS000506

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS000506

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS000506

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP-Rule MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1091 By similarity HAMAP-Rule MF_00435

Sequences

Sequence LengthMass (Da)Tools
C7BYR6 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 2755D1FDFB394354

FASTA33036,611
        10         20         30         40         50         60 
MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVRVRIGLYQ GSLSVSKAKK 

        70         80         90        100        110        120 
EGFEVLEIKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK EGQIIGFAHG FSVHFNQVIL 

       130        140        150        160        170        180 
PKGVGAILVA PKGPGSALRE EYLKNKGLYH LIAIEQESSK NNAKAVALSY AKAMGGGRMG 

       190        200        210        220        230        240 
VLETSFKEEC ESDLFGEQAV LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL 

       250        260        270        280        290        300 
LHYKGVEGLR KHISNTAEFG AIKAREPMAN LLEKRMQKIL KKIQNGSFAK DFLLEKSLNY 

       310        320        330 
PRLNTERKAL KETKIEQIGE ILRAPFNHKK

« Hide

References

[1]"From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma."
Thiberge J.M., Boursaux-Eude C., Lehours P., Dillies M.A., Creno S., Coppee J.Y., Rouy Z., Lajus A., Ma L., Burucoa C., Ruskone-Foumestraux A., Courillon-Mallet A., De Reuse H., Gomperts Boneca I., Lamarque D., Megraud F., Delchier J.C., Medigue C. expand/collapse author list , Bouchier C., Labigne A., Raymond J.
BMC Genomics 11:368-368(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B38 EMBL CAX28877.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM991728 Genomic DNA. Translation: CAX28877.1.
RefSeqYP_003057133.1. NC_012973.1.

3D structure databases

ProteinModelPortalC7BYR6.
ModBaseSearch...

Protein-protein interaction databases

STRING592205.HELPY_0334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAX28877; CAX28877; HELPY_0334.
GeneID8208335.
KEGGhpb:HELPY_0334.
PATRIC20595310. VBIHelPyl144313_0336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAMAYAKGI.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycHPYL592205:GJAG-330-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7BYR6_HELPB
AccessionPrimary (citable) accession number: C7BYR6
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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