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C7BTH7

- C7BTH7_PHOAA

UniProt

C7BTH7 - C7BTH7_PHOAA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPASY291112:GJQ0-1807-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:PAU_01740Imported
OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))Imported
Taxonomic identifieri553480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002747: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi291112.PAU_01740.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7BTH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVIPAE GKKITVDAKG KLVVPNNPVI PYIEGDGIGV DVTPAMLKVV
60 70 80 90 100
DAAVQTAYQG ERKISWMEIY TGEKSTHVYG KDVWLPDETL DLIREYRVAI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYQGTPS PVKQPELTDM
160 170 180 190 200
VIFRENAEDI YAGIEWKAGS AEADKVIKFL QDEMGVSKIR FPQQCGIGVK
210 220 230 240 250
PCSEEGTKRL VRAAIEYAID NDRESVTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGGELLD GGPWVKINNP KNGKEIIVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ACMNLNGDYI SDALAAQVGG IGIAPGANIG DECALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSVILS AEMMLRHMGW TEAADLIVKG MEGAIAAKTV TYDFERLMEG
410
AKLLKCSEFG DAIIQHM
Length:417
Mass (Da):45,656
Last modified:September 22, 2009 - v1
Checksum:i00ADDA348C3BE8A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ83832.1.
RefSeqiYP_003040576.1. NC_012962.1.

Genome annotation databases

EnsemblBacteriaiCAQ83832; CAQ83832; PAU_01740.
GeneIDi13859133.
KEGGipay:PAU_01740.
PATRICi20497304. VBIPhoAsy71438_1921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ83832.1 .
RefSeqi YP_003040576.1. NC_012962.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291112.PAU_01740.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ83832 ; CAQ83832 ; PAU_01740 .
GeneIDi 13859133.
KEGGi pay:PAU_01740.
PATRICi 20497304. VBIPhoAsy71438_1921.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci PASY291112:GJQ0-1807-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43949 / 3105-77Imported.

Entry informationi

Entry nameiC7BTH7_PHOAA
AccessioniPrimary (citable) accession number: C7BTH7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3