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C7BJY6

- C7BJY6_PHOAA

UniProt

C7BJY6 - C7BJY6_PHOAA

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Protein
4-hydroxy-tetrahydrodipicolinate reductase
Gene
dapB, PAU_00560
Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NAD By similarityUniRule annotation
Binding sitei39 – 391NADP By similarityUniRule annotation
Active sitei159 – 1591Proton donor/acceptor By similarityUniRule annotation
Binding sitei160 – 1601Substrate By similarityUniRule annotation
Active sitei163 – 1631Proton donor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD(P) By similarityUniRule annotation
Nucleotide bindingi102 – 1043NAD(P) By similarityUniRule annotation
Nucleotide bindingi126 – 1294NAD(P) By similarityUniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotations, Lysine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations, NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPASY291112:GJQ0-577-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotationImported
Ordered Locus Names:PAU_00560Imported
OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Taxonomic identifieri553480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002747: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi291112.PAU_00560.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1702Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227153.
KOiK00215.
OMAiHTVWFAD.
OrthoDBiEOG6SV5DS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7BJY6-1 [UniParc]FASTAAdd to Basket

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MADTDIRVAI VGAGGRMGRQ LIQAVHQLSG VVLGVALERS GSSLLGTDAG    50
ELAGIGHIGV TVCDDLKNVV DDFDVLIDFT RPEGTLAHLE ICRRHSKAIV 100
IGTTGFDDEG KQAIKDASAN IPIVFAANFS VGVNLVLKLL EKAAKVMGEY 150
TDIEIIEAHH RHKVDAPSGT ALAMGESIAH ALGRDLKECA VYAREGYTGE 200
RDPKSIGFAT IRAGDIVGEH TAMFADVGER VEITHKASSR MTFANGAVKA 250
ALWLNGKNSG LFTMKDVLNL DLI 273
Length:273
Mass (Da):28,957
Last modified:September 22, 2009 - v1
Checksum:i9C657FA42BE8EEB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM162591 Genomic DNA. Translation: CAQ82652.1.
RefSeqiYP_003039397.1. NC_012962.1.

Genome annotation databases

EnsemblBacteriaiCAQ82652; CAQ82652; PAU_00560.
GeneIDi13863305.
KEGGipay:PAU_00560.
PATRICi20494709. VBIPhoAsy71438_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM162591 Genomic DNA. Translation: CAQ82652.1 .
RefSeqi YP_003039397.1. NC_012962.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 291112.PAU_00560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ82652 ; CAQ82652 ; PAU_00560 .
GeneIDi 13863305.
KEGGi pay:PAU_00560.
PATRICi 20494709. VBIPhoAsy71438_0644.

Phylogenomic databases

HOGENOMi HOG000227153.
KOi K00215.
OMAi HTVWFAD.
OrthoDBi EOG6SV5DS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci PASY291112:GJQ0-577-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43949 / 3105-77.

Entry informationi

Entry nameiC7BJY6_PHOAA
AccessioniPrimary (citable) accession number: C7BJY6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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