Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C7BJY6

- C7BJY6_PHOAA

UniProt

C7BJY6 - C7BJY6_PHOAA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NADUniRule annotation
Binding sitei39 – 391NADPUniRule annotation
Active sitei159 – 1591Proton donor/acceptorUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Active sitei163 – 1631Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD(P)UniRule annotation
Nucleotide bindingi102 – 1043NAD(P)UniRule annotation
Nucleotide bindingi126 – 1294NAD(P)UniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPASY291112:GJQ0-577-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotationSAAS annotation (EC:1.17.1.8UniRule annotationSAAS annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotationImported
Ordered Locus Names:PAU_00560Imported
OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))Imported
Taxonomic identifieri553480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002747: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi291112.PAU_00560.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1702Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227153.
KOiK00215.
OMAiHTVWFAD.
OrthoDBiEOG6SV5DS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7BJY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTDIRVAI VGAGGRMGRQ LIQAVHQLSG VVLGVALERS GSSLLGTDAG
60 70 80 90 100
ELAGIGHIGV TVCDDLKNVV DDFDVLIDFT RPEGTLAHLE ICRRHSKAIV
110 120 130 140 150
IGTTGFDDEG KQAIKDASAN IPIVFAANFS VGVNLVLKLL EKAAKVMGEY
160 170 180 190 200
TDIEIIEAHH RHKVDAPSGT ALAMGESIAH ALGRDLKECA VYAREGYTGE
210 220 230 240 250
RDPKSIGFAT IRAGDIVGEH TAMFADVGER VEITHKASSR MTFANGAVKA
260 270
ALWLNGKNSG LFTMKDVLNL DLI
Length:273
Mass (Da):28,957
Last modified:September 22, 2009 - v1
Checksum:i9C657FA42BE8EEB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ82652.1.
RefSeqiYP_003039397.1. NC_012962.1.

Genome annotation databases

EnsemblBacteriaiCAQ82652; CAQ82652; PAU_00560.
GeneIDi13863305.
KEGGipay:PAU_00560.
PATRICi20494709. VBIPhoAsy71438_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ82652.1 .
RefSeqi YP_003039397.1. NC_012962.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291112.PAU_00560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ82652 ; CAQ82652 ; PAU_00560 .
GeneIDi 13863305.
KEGGi pay:PAU_00560.
PATRICi 20494709. VBIPhoAsy71438_0644.

Phylogenomic databases

HOGENOMi HOG000227153.
KOi K00215.
OMAi HTVWFAD.
OrthoDBi EOG6SV5DS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci PASY291112:GJQ0-577-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43949 / 3105-77Imported.

Entry informationi

Entry nameiC7BJY6_PHOAA
AccessioniPrimary (citable) accession number: C7BJY6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3