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C7BII3

- C7BII3_PHOAA

UniProt

C7BII3 - C7BII3_PHOAA

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Protein

Thymidine kinase

Gene

tdk

Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi182 – 1821ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPASY291112:GJQ0-2102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:PAU_02029Imported
OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))Imported
Taxonomic identifieri553480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002747: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi291112.PAU_02029.

Structurei

3D structure databases

ProteinModelPortaliC7BII3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7BII3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTSLL QSSYNYNERG MRTLIFTAEI DTRFGKGKIS
60 70 80 90 100
SRLGLSADAF LFSQQTDIGE LIRNENKQET VHCVLVDECQ FLTKEQVEQL
110 120 130 140 150
CKVTDYDDIP VLCYGLRTDF RGELFSGSQY LLAWADKLVE LKTICHCGRK
160 170 180 190 200
ASRVLRFDNE GVVICDGDQV DIGGNEKYVS VCRKHYTDAI NEAKEERRDN

M
Length:201
Mass (Da):22,954
Last modified:September 22, 2009 - v1
Checksum:i18FCE355801C0CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ84121.1.
RefSeqiYP_003040865.1. NC_012962.1.

Genome annotation databases

EnsemblBacteriaiCAQ84121; CAQ84121; PAU_02029.
GeneIDi13863292.
KEGGipay:PAU_02029.
PATRICi20497924. VBIPhoAsy71438_2230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ84121.1 .
RefSeqi YP_003040865.1. NC_012962.1.

3D structure databases

ProteinModelPortali C7BII3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291112.PAU_02029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ84121 ; CAQ84121 ; PAU_02029 .
GeneIDi 13863292.
KEGGi pay:PAU_02029.
PATRICi 20497924. VBIPhoAsy71438_2230.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci PASY291112:GJQ0-2102-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43949 / 3105-77Imported.

Entry informationi

Entry nameiC7BII3_PHOAA
AccessioniPrimary (citable) accession number: C7BII3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3