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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPASY291112:GJQ0-3333-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotationSAAS annotation (EC:1.2.1.41UniRule annotationSAAS annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:PAU_03217Imported
OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))Imported
Taxonomic identifieri553480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002747: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi291112.PAU_03217.

Structurei

3D structure databases

ProteinModelPortaliC7BHW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7BHW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEQMGKAAR EASWQLAQLS TKQKNQALIH IADLLEQESA VILEANQLDM
60 70 80 90 100
IQAREQGMNE ALLDRLLLTS ERLTAIANDV RQVCRLSDPV GQIIDGSLLD
110 120 130 140 150
SGLKLERRRV PLGVVGVIYE ARPNVTIDVA SLCLKTGNAV ILRGGKETHN
160 170 180 190 200
TNQATVKVIQ RALEQSGLPA AAVQVIDKPD RELVTQLLKM DRYVDMLIPR
210 220 230 240 250
GGAGLHKLCR EQSTIPVITG GIGVCHIFVD ESVDFNQALT VITNAKVQRP
260 270 280 290 300
SACNALETLL VHEKIAADFL PALSENMKAQ GVTLHASKSA MEFLLEGPAK
310 320 330 340 350
VVEVTEVDYS DEWLSLDMNV EIVSDIEQAI NHIRTYGTSH SDAILTQSLH
360 370 380 390 400
NADYFVRQVD SAAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLD
410
ALTTYKWVGY GDDLIRQ
Length:417
Mass (Da):45,541
Last modified:September 22, 2009 - v1
Checksum:i8D4AF9D75CD60662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ85305.1.
RefSeqiYP_003042047.1. NC_012962.1.

Genome annotation databases

EnsemblBacteriaiCAQ85305; CAQ85305; PAU_03217.
GeneIDi13860018.
KEGGipay:PAU_03217.
PATRICi20500756. VBIPhoAsy71438_3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM162591 Genomic DNA. Translation: CAQ85305.1.
RefSeqiYP_003042047.1. NC_012962.1.

3D structure databases

ProteinModelPortaliC7BHW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi291112.PAU_03217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ85305; CAQ85305; PAU_03217.
GeneIDi13860018.
KEGGipay:PAU_03217.
PATRICi20500756. VBIPhoAsy71438_3616.

Phylogenomic databases

HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.
BioCyciPASY291112:GJQ0-3333-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43949 / 3105-77Imported.

Entry informationi

Entry nameiC7BHW3_PHOAA
AccessioniPrimary (citable) accession number: C7BHW3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.