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C7BHW3

- C7BHW3_PHOAA

UniProt

C7BHW3 - C7BHW3_PHOAA

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation
    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.SAAS annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPASY291112:GJQ0-3333-MONOMER.
    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotation
    Ordered Locus Names:PAU_03217Imported
    OrganismiPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2))Imported
    Taxonomic identifieri553480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002747: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi291112.PAU_03217.

    Structurei

    3D structure databases

    ProteinModelPortaliC7BHW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiALTSYKW.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7BHW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEQMGKAAR EASWQLAQLS TKQKNQALIH IADLLEQESA VILEANQLDM    50
    IQAREQGMNE ALLDRLLLTS ERLTAIANDV RQVCRLSDPV GQIIDGSLLD 100
    SGLKLERRRV PLGVVGVIYE ARPNVTIDVA SLCLKTGNAV ILRGGKETHN 150
    TNQATVKVIQ RALEQSGLPA AAVQVIDKPD RELVTQLLKM DRYVDMLIPR 200
    GGAGLHKLCR EQSTIPVITG GIGVCHIFVD ESVDFNQALT VITNAKVQRP 250
    SACNALETLL VHEKIAADFL PALSENMKAQ GVTLHASKSA MEFLLEGPAK 300
    VVEVTEVDYS DEWLSLDMNV EIVSDIEQAI NHIRTYGTSH SDAILTQSLH 350
    NADYFVRQVD SAAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLD 400
    ALTTYKWVGY GDDLIRQ 417
    Length:417
    Mass (Da):45,541
    Last modified:September 22, 2009 - v1
    Checksum:i8D4AF9D75CD60662
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM162591 Genomic DNA. Translation: CAQ85305.1.
    RefSeqiYP_003042047.1. NC_012962.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ85305; CAQ85305; PAU_03217.
    GeneIDi13860018.
    KEGGipay:PAU_03217.
    PATRICi20500756. VBIPhoAsy71438_3616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM162591 Genomic DNA. Translation: CAQ85305.1 .
    RefSeqi YP_003042047.1. NC_012962.1.

    3D structure databases

    ProteinModelPortali C7BHW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291112.PAU_03217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ85305 ; CAQ85305 ; PAU_03217 .
    GeneIDi 13860018.
    KEGGi pay:PAU_03217.
    PATRICi 20500756. VBIPhoAsy71438_3616.

    Phylogenomic databases

    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi ALTSYKW.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .
    BioCyci PASY291112:GJQ0-3333-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43949 / 3105-77Imported.

    Entry informationi

    Entry nameiC7BHW3_PHOAA
    AccessioniPrimary (citable) accession number: C7BHW3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3