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C7BHW3 (C7BHW3_PHOAA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP-Rule MF_00412

Short name=GPR HAMAP-Rule MF_00412
EC=1.2.1.41 HAMAP-Rule MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Gene names
Name:proA HAMAP-Rule MF_00412
Ordered Locus Names:PAU_03217 EMBL CAQ85305.1
OrganismPhotorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77) (Xenorhabdus luminescens (strain 2)) [Complete proteome] [HAMAP]
Taxonomic identifier553480 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP-Rule MF_00412 SAAS SAAS000965

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP-Rule MF_00412 SAAS SAAS000965

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP-Rule MF_00412 SAAS SAAS000965

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00412 SAAS SAAS000965.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP-Rule MF_00412

Sequences

Sequence LengthMass (Da)Tools
C7BHW3 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 8D4AF9D75CD60662

FASTA41745,541
        10         20         30         40         50         60 
MLEQMGKAAR EASWQLAQLS TKQKNQALIH IADLLEQESA VILEANQLDM IQAREQGMNE 

        70         80         90        100        110        120 
ALLDRLLLTS ERLTAIANDV RQVCRLSDPV GQIIDGSLLD SGLKLERRRV PLGVVGVIYE 

       130        140        150        160        170        180 
ARPNVTIDVA SLCLKTGNAV ILRGGKETHN TNQATVKVIQ RALEQSGLPA AAVQVIDKPD 

       190        200        210        220        230        240 
RELVTQLLKM DRYVDMLIPR GGAGLHKLCR EQSTIPVITG GIGVCHIFVD ESVDFNQALT 

       250        260        270        280        290        300 
VITNAKVQRP SACNALETLL VHEKIAADFL PALSENMKAQ GVTLHASKSA MEFLLEGPAK 

       310        320        330        340        350        360 
VVEVTEVDYS DEWLSLDMNV EIVSDIEQAI NHIRTYGTSH SDAILTQSLH NADYFVRQVD 

       370        380        390        400        410 
SAAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLD ALTTYKWVGY GDDLIRQ 

« Hide

References

[1]"Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens."
Wilkinson P., Waterfield N.R., Crossman L., Corton C., Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L., Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C., Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.
BMC Genomics 10:302-302(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43949 / 3105-77.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM162591 Genomic DNA. Translation: CAQ85305.1.
RefSeqYP_003042047.1. NC_012962.1.

3D structure databases

ProteinModelPortalC7BHW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING291112.PAU_03217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ85305; CAQ85305; PAU_03217.
GeneID13860018.
KEGGpay:PAU_03217.
PATRIC20500756. VBIPhoAsy71438_3616.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000246356.
KOK00147.
OMACNAIETL.
OrthoDBEOG6FFSCX.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycPASY291112:GJQ0-3333-MONOMER.
UniPathwayUPA00098; UER00360.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPMF_00412. ProA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PANTHERPTHR11063:SF1. PTHR11063:SF1. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00407. proA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7BHW3_PHOAA
AccessionPrimary (citable) accession number: C7BHW3
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)