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Protein
Submitted name:

TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi327 – 395HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14Imported
Submitted name:
Transcription factor 7-like 2Imported
Submitted name:
Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_iImported
Gene namesi
Name:TCF7L2Imported
ORF Names:hCG_40998Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11641. TCF7L2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737.
PharmGKBiPA36394.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiC6ZRK5. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiC6ZRK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 395HMG box DNA-bindingInterPro annotationAdd BLAST69

Phylogenomic databases

GeneTreeiENSGT00390000009964.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028773. TCF7L2.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF44. PTHR10373:SF44. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C6ZRK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTYLQ MKWPLLDVQA GSLQSRQALK
160 170 180 190 200
DARSPSPAHI VSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD
210 220 230 240 250
VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT
260 270 280 290 300
GGFRHPYPTA LTVNASMSRF PPHMVPPHHT LHTTGIPHPA IVTPTVKQES
310 320 330 340 350
SQSDVGSLHS SKHQDSKKEE EKKKPHIKKP LNAFMLYMKE MRAKVVAECT
360 370 380 390 400
LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL YPGWSARDNY
410 420 430 440 450
GKKKKRKRDK QPGETNDLSA PKKCRARFGL DQQNNWCGPC RRKKKCVRYI
460 470 480 490 500
QGEGSCLSPP SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP
510 520 530 540 550
DPLAHLSMMP PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA
560 570
QPSTSSLHSH SSLAGTQPQP LSLVTKSLE
Length:579
Mass (Da):63,409
Last modified:September 22, 2009 - v1
Checksum:i900E2A3AE7F4A2CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA. No translation available.
AL158212 Genomic DNA. No translation available.
AL445486 Genomic DNA. No translation available.
AL451084 Genomic DNA. No translation available.
FJ010174 mRNA. Translation: ACI28532.1.
CH471066 Genomic DNA. Translation: EAW49514.1.
RefSeqiNP_001139757.1. NM_001146285.1.
UniGeneiHs.593995.

Genome annotation databases

EnsembliENST00000536810; ENSP00000446238; ENSG00000148737.
GeneIDi6934.
UCSCiuc001laf.5. human.

Similar proteinsi

Entry informationi

Entry nameiC6ZRK5_HUMAN
AccessioniPrimary (citable) accession number: C6ZRK5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported