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Protein
Submitted name:

TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,4a-11,12,13a,14

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi265 – 333HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,4a-11,12,13a,14Imported
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15.
HGNCiHGNC:11641. TCF7L2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiC6ZRJ6. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 333HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

GeneTreeiENSGT00390000009964.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR024940. TCF/LEF.
PANTHERiPTHR10373. PTHR10373. 2 hits.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C6ZRJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPDLTSPYL PNGSLSPTAR TYLQMKWPLL DVQAGSLQSR QALKDARSPS
60 70 80 90 100
PAHIVQSPLP CCTQGHDCQH FYPPSDFTVS TQVFRDMKRS HSLQKVGEPW
110 120 130 140 150
CIESNKVPVV QHPHHVHPLT PLITYSNEHF TPGNPPPHLP ADVDPKTGIP
160 170 180 190 200
RPPHPPDISP YYPLSPGTVG QIPHPLGWQG QPVYPITTGG FRHPYPTALT
210 220 230 240 250
VNASMSRFPP HMVPPHHTLH TTGIPHPAIV TPTVKQESSQ SDVGSLHSSK
260 270 280 290 300
HQDSKKEEEK KKPHIKKPLN AFMLYMKEMR AKVVAECTLK ESAAINQILG
310 320 330 340 350
RRWHALSREE QAKYYELARK ERQLHMQLYP GWSARDNYGK KKKRKRDKQP
360 370 380 390 400
GETNEHSECF LNPCLSLPPI TDANTPKKCR ALFGLDRQTL WCKPCRRKKK
410 420 430 440 450
CVRYIQGEGS CLSPPSSDGS LLDSPPPSPN LLGSPPRDAK SQTEQTQPLS
460 470 480 490 500
LSLKPDPLAH LSMMPPPPAL LLAEATHKAS ALCPNGALDL PPAALQPAAP
510 520 530
SSSIAQPSTS SLHSHSSLAG TQPQPLSLVT KSLE
Length:534
Mass (Da):58,881
Last modified:September 22, 2009 - v1
Checksum:i082946971807B616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA. No translation available.
AL158212 Genomic DNA. No translation available.
AL445486 Genomic DNA. No translation available.
AL451084 Genomic DNA. No translation available.
FJ010165 mRNA. Translation: ACI28523.1.
UniGeneiHs.593995.

Genome annotation databases

EnsembliENST00000542695; ENSP00000443883; ENSG00000148737.
UCSCiuc057wba.1. human.

Similar proteinsi

Entry informationi

Entry nameiC6ZRJ6_HUMAN
AccessioniPrimary (citable) accession number: C6ZRJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported