C6YLX0 (C6YLX0_VIBCH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
Short name=STH HAMAP MF_00247
EC=1.6.1.1 HAMAP MF_00247

Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific] HAMAP MF_00247

Gene names

Name:	sthA HAMAP MF_00247
ORF Names:	VchoM_03683 EMBL EET25656.1

Organism

Vibrio cholerae MO10 EMBL EET25656.1

Taxonomic identifier

345072 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247 SAAS SAAS004099
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247 SAAS SAAS004099
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_00247 SAAS SAAS004099
Subcellular location	Cytoplasm By similarity HAMAP MF_00247.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. HAMAP MF_00247

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00247 SAAS SAAS004099
Ligand	FAD HAMAP MF_00247 SAAS SAAS022962 Flavoprotein HAMAP MF_00247 SAAS SAAS004099 NAD HAMAP MF_00247 SAAS SAAS004099 NADP HAMAP MF_00247 SAAS SAAS004099
Molecular function	Oxidoreductase HAMAP MF_00247 SAAS SAAS004099
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity HAMAP MF_00247

Sequences

	Sequence		Length	Mass (Da)
	C6YLX0 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 60D05DB3FD595BE1	FASTA	466	50,942
	10 20 30 40 50 60 MGQKNHFDVI VIGSGPGGEG AAMGLTKGGK NVAIIEKESS VGGGCTHWGT IPSKALRHAV 70 80 90 100 110 120 SRIIEFNSNP LFCKNNSSIH ATFSTILSHA KSVIDKQTRL RQGFYDRNQC TLIFGAAHFI 130 140 150 160 170 180 DAHTVAVKKA DGSIDTYSAD KFVIATGSRP YHPKDVDFGH PRIYDSDSIL NLEHDPRHII 190 200 210 220 230 240 IYGAGVIGCE YASIFRGLDV KTDLINTRDR LLSFLDNEVS DALSYHFWNS GVVIRNDETY 250 260 270 280 290 300 DKVEGTSDGV IVHLKSGKKM RADCLLYANG RTGNTDKLNL ESVGLQADSR GQLVVNANYQ 310 320 330 340 350 360 TQVEHIYAVG DVIGYPSLAS AAYDQGRFVA QAIIHGQAAH LLTEDIPTGI YTIPEISSVG 370 380 390 400 410 420 RTEQELTAAK VPYEVGRASF KHLARAQIAG KDIGSLKILF HRETKEILGI HCFGERAAEI 430 440 450 460 IHIGQAIMEQ KGEANTIEYF VNTTFNYPTM AEAFRVAALN GLNRLF

References

[1]

"Annotation of Vibrio cholerae MO10." Colwell R., Grim C.J., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Shea T., Sykes S., Yandava C., Alvarado L., Kodira C., Borodovsky M., Heidelberg J., Lander E., Galagan J., Nusbaum C., Birren B. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: MO10 EMBL EET25656.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS990141 Genomic DNA. Translation: EET25656.1.
3D structure databases
ProteinModelPortal	C6YLX0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	28068896. VBIVibCho130181_3485.
Phylogenomic databases
OMA	GEGNTIE.
Family and domain databases
HAMAP	MF_00247. SthA. [Tree]
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR022962. STH. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6YLX0_VIBCH

Accession

Primary (citable) accession number: C6YLX0

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)