ID   C6YB47_HUMAN            Unreviewed;       354 AA.
AC   C6YB47;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
GN   Name=BRCA1 {ECO:0000313|EMBL:ABC88652.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABC88652.1};
RN   [1] {ECO:0000313|EMBL:ABC88652.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Miao L.X., Zheng C.Y.;
RT   "Cloning and characterization of a new alternative splice variant of
RT   BRCA1.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DQ363751; ABC88652.1; -; mRNA.
DR   AlphaFoldDB; C6YB47; -.
DR   PeptideAtlas; C6YB47; -.
DR   ChiTaRS; BRCA1; human.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd17735; BRCT_BRCA1_rpt1; 1.
DR   CDD; cd17721; BRCT_BRCA1_rpt2; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 2.
DR   InterPro; IPR031099; BRCA1-associated.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR   Pfam; PF00533; BRCT; 2.
DR   PIRSF; PIRSF001734; BRCA1; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   PROSITE; PS50172; BRCT; 2.
PE   2: Evidence at transcript level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          133..227
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          247..346
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   REGION          26..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  39774 MW;  8E5B0B7CF73FE51F CRC64;
     MHSCSGSLQN RNYPSQEELI KVVDVEEQQL EESGPHDLTE TSYLPRQDLE GTPYLESGIS
     LFSDDPESDP SEDRAPESAR VGNIPSSTSA LKVPQLKVAE SAQGPAAAHT TDTAGYNAME
     ESVSREKPEL TASTERVNKR MSMVVSGLTP EEFMLVYKFA RKHHITLTNL ITEETTHVVM
     KTDAEFVCER TLKYFLGIAG GKWVVSYFWV TQSIKERKML NEHDFEVRGD VVNGRNHQGP
     KRARESQDRK IFRGLEICCY GPFTNMPTDQ LEWMVQLCGA SVVKELSSFT LGTGVHPIVV
     VQPDAWTEDN GFHAIGQMCE TPVVTREWVL DSVALYQCQE LDTYLIPQIP HSHY
//