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C6Y444

- C6Y444_PEDHD

UniProt

C6Y444 - C6Y444_PEDHD

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Protein

ATP-dependent 6-phosphofructokinase

Gene
pfkA, Phep_3293
Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi107 – 1071Magnesium; catalytic By similarityUniRule annotation
Active sitei132 – 1321Proton acceptor By similarityUniRule annotation
Binding sitei159 – 1591Allosteric activator ADP By similarityUniRule annotation
Binding sitei167 – 1671Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei227 – 2271Substrate By similarityUniRule annotation
Binding sitei251 – 2511Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 772ATP By similarityUniRule annotation
Nucleotide bindingi106 – 1094ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHEP485917:GHL9-3329-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Phep_3293Imported
OrganismiPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)Imported
Taxonomic identifieri485917 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaePedobacter
ProteomesiUP000000852: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi485917.Phep_3293.

Structurei

3D structure databases

ProteinModelPortaliC6Y444.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 295Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni130 – 1323Substrate binding By similarityUniRule annotation
Regioni174 – 1763Substrate binding By similarityUniRule annotation
Regioni190 – 1923Allosteric activator ADP binding By similarityUniRule annotation
Regioni218 – 2203Allosteric activator ADP binding By similarityUniRule annotation
Regioni257 – 2604Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000248870.
KOiK00850.
OMAiISEGAFP.
OrthoDBiEOG644ZRM.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6Y444-1 [UniParc]FASTAAdd to Basket

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MKPNIKNIAV LTSGGDAPGM NACIRAVVRT GIYNGINMFG VLQGYQGLIS    50
NNINPMDARS VSNIIHLGGT ILKTARCLEF KTDEGMALAY ENMKARDIDG 100
LVVIGGDGTF TGAKRFGEKF GIRVMGVPGT IDNDLYGSDF TLGYDTAINT 150
VIEAIDKIRD TADSHDRLFF IEVMGRDSGC IALRSAISSG AEAVLLPEKE 200
TSLNELISML ETGASTKKTS SIVIVSEGHK DGGAYEVAKK VKERFNHYDT 250
KVTILGHLQR GGSPSSFDRI LGSRLGFAAV NELLKGNTME MVGLRGNEVK 300
TTSIEEALTR HTFKLESDLL EMTKVLSI 328
Length:328
Mass (Da):35,364
Last modified:September 22, 2009 - v1
Checksum:i9227CB8DABFC3229
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001681 Genomic DNA. Translation: ACU05487.1.
RefSeqiYP_003093549.1. NC_013061.1.

Genome annotation databases

EnsemblBacteriaiACU05487; ACU05487; Phep_3293.
GeneIDi8254412.
KEGGiphe:Phep_3293.
PATRICi22883743. VBIPedHep98714_3336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001681 Genomic DNA. Translation: ACU05487.1 .
RefSeqi YP_003093549.1. NC_013061.1.

3D structure databases

ProteinModelPortali C6Y444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485917.Phep_3293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU05487 ; ACU05487 ; Phep_3293 .
GeneIDi 8254412.
KEGGi phe:Phep_3293.
PATRICi 22883743. VBIPedHep98714_3336.

Phylogenomic databases

eggNOGi COG0205.
HOGENOMi HOG000248870.
KOi K00850.
OMAi ISEGAFP.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci PHEP485917:GHL9-3329-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13125 / DSM 2366 / NCIB 9290.

Entry informationi

Entry nameiC6Y444_PEDHD
AccessioniPrimary (citable) accession number: C6Y444
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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