Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C6Y444

- C6Y444_PEDHD

UniProt

C6Y444 - C6Y444_PEDHD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.UniRule annotationSAAS annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotationSAAS annotation

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151ATP; via amide nitrogenUniRule annotation
Metal bindingi107 – 1071Magnesium; catalyticUniRule annotation
Active sitei132 – 1321Proton acceptorUniRule annotation
Binding sitei159 – 1591Allosteric activator ADPUniRule annotation
Binding sitei167 – 1671Substrate; shared with dimeric partnerUniRule annotation
Binding sitei227 – 2271SubstrateUniRule annotation
Binding sitei251 – 2511Substrate; shared with dimeric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 772ATPUniRule annotation
Nucleotide bindingi106 – 1094ATPUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHEP485917:GHL9-3329-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
PhosphohexokinaseUniRule annotation
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Phep_3293Imported
OrganismiPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)Imported
Taxonomic identifieri485917 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaePedobacter
ProteomesiUP000000852: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi485917.Phep_3293.

Structurei

3D structure databases

ProteinModelPortaliC6Y444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 295Allosteric activator ADP binding; shared with dimeric partnerUniRule annotation
Regioni130 – 1323Substrate bindingUniRule annotation
Regioni174 – 1763Substrate bindingUniRule annotation
Regioni190 – 1923Allosteric activator ADP bindingUniRule annotation
Regioni218 – 2203Allosteric activator ADP bindingUniRule annotation
Regioni257 – 2604Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade "B1" sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000248870.
KOiK00850.
OMAiISEGAFP.
OrthoDBiEOG644ZRM.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok-type.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6Y444-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPNIKNIAV LTSGGDAPGM NACIRAVVRT GIYNGINMFG VLQGYQGLIS
60 70 80 90 100
NNINPMDARS VSNIIHLGGT ILKTARCLEF KTDEGMALAY ENMKARDIDG
110 120 130 140 150
LVVIGGDGTF TGAKRFGEKF GIRVMGVPGT IDNDLYGSDF TLGYDTAINT
160 170 180 190 200
VIEAIDKIRD TADSHDRLFF IEVMGRDSGC IALRSAISSG AEAVLLPEKE
210 220 230 240 250
TSLNELISML ETGASTKKTS SIVIVSEGHK DGGAYEVAKK VKERFNHYDT
260 270 280 290 300
KVTILGHLQR GGSPSSFDRI LGSRLGFAAV NELLKGNTME MVGLRGNEVK
310 320
TTSIEEALTR HTFKLESDLL EMTKVLSI
Length:328
Mass (Da):35,364
Last modified:September 22, 2009 - v1
Checksum:i9227CB8DABFC3229
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001681 Genomic DNA. Translation: ACU05487.1.
RefSeqiWP_015809096.1. NC_013061.1.
YP_003093549.1. NC_013061.1.

Genome annotation databases

EnsemblBacteriaiACU05487; ACU05487; Phep_3293.
GeneIDi8254412.
KEGGiphe:Phep_3293.
PATRICi22883743. VBIPedHep98714_3336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001681 Genomic DNA. Translation: ACU05487.1 .
RefSeqi WP_015809096.1. NC_013061.1.
YP_003093549.1. NC_013061.1.

3D structure databases

ProteinModelPortali C6Y444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485917.Phep_3293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU05487 ; ACU05487 ; Phep_3293 .
GeneIDi 8254412.
KEGGi phe:Phep_3293.
PATRICi 22883743. VBIPedHep98714_3336.

Phylogenomic databases

eggNOGi COG0205.
HOGENOMi HOG000248870.
KOi K00850.
OMAi ISEGAFP.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci PHEP485917:GHL9-3329-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok-type.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13125 / DSM 2366 / NCIB 9290Imported.

Entry informationi

Entry nameiC6Y444_PEDHD
AccessioniPrimary (citable) accession number: C6Y444
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome, Reference proteomeImported

External Data

Dasty 3