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C6Y231

- C6Y231_PEDHD

UniProt

C6Y231 - C6Y231_PEDHD

Protein

Thymidine kinase

Gene

tdk

Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton acceptorUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi154 – 1541ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 298ATPUniRule annotation
    Nucleotide bindingi94 – 974ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPHEP485917:GHL9-808-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Phep_0802Imported
    OrganismiPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)Imported
    Taxonomic identifieri485917 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaePedobacter
    ProteomesiUP000000852: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi485917.Phep_0802.

    Structurei

    3D structure databases

    ProteinModelPortaliC6Y231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6Y231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFSEQNYRR GEYCGSIEVI CGSMFSGKTE ELLRRLKRAQ IAKLNVEIFK    50
    PKTDTRYDET AVVSHDLNSI QSTPVENSAA ILLLGANTQV VGIDEAQFFD 100
    DNLPEVCNKL AQKGIRVIVA GLDMDFQGKP FGPVPALMAI AELVTKVNAV 150
    CVRCGSPAVY SYRTAASEST ILLGEKDSYE PRCRHCYHLG DMA 193
    Length:193
    Mass (Da):21,271
    Last modified:September 22, 2009 - v1
    Checksum:i8D4A8B7D4BF0B193
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001681 Genomic DNA. Translation: ACU03024.1.
    RefSeqiWP_012780970.1. NC_013061.1.
    YP_003091086.1. NC_013061.1.

    Genome annotation databases

    EnsemblBacteriaiACU03024; ACU03024; Phep_0802.
    GeneIDi8251891.
    KEGGiphe:Phep_0802.
    PATRICi22878649. VBIPedHep98714_0820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001681 Genomic DNA. Translation: ACU03024.1 .
    RefSeqi WP_012780970.1. NC_013061.1.
    YP_003091086.1. NC_013061.1.

    3D structure databases

    ProteinModelPortali C6Y231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 485917.Phep_0802.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU03024 ; ACU03024 ; Phep_0802 .
    GeneIDi 8251891.
    KEGGi phe:Phep_0802.
    PATRICi 22878649. VBIPedHep98714_0820.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci PHEP485917:GHL9-808-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13125 / DSM 2366 / NCIB 9290Imported.

    Entry informationi

    Entry nameiC6Y231_PEDHD
    AccessioniPrimary (citable) accession number: C6Y231
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3