ID   C6XY00_PEDHD            Unreviewed;       549 AA.
AC   C6XY00;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Glycosyl hydrolase BNR repeat-containing protein {ECO:0000313|EMBL:ACU04418.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:ACU04418.1};
GN   OrderedLocusNames=Phep_2214 {ECO:0000313|EMBL:ACU04418.1};
OS   Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457
OS   / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3).
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=485917 {ECO:0000313|EMBL:ACU04418.1, ECO:0000313|Proteomes:UP000000852};
RN   [1] {ECO:0000313|EMBL:ACU04418.1, ECO:0000313|Proteomes:UP000000852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 /
RC   NCIMB 9290 / NRRL B-14731 / HIM 762-3
RC   {ECO:0000313|Proteomes:UP000000852};
RX   PubMed=21304637; DOI=10.4056/sigs.22138;
RA   Han C., Spring S., Lapidus A., Del Rio T.G., Tice H., Copeland A.,
RA   Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.C., Saunders E., Chertkov O.,
RA   Brettin T., Goker M., Rohde M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of Pedobacter heparinus type strain (HIM 762-
RT   3).";
RL   Stand. Genomic Sci. 1:54-62(2009).
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DR   EMBL; CP001681; ACU04418.1; -; Genomic_DNA.
DR   RefSeq; WP_015808031.1; NZ_AQGK01000001.1.
DR   AlphaFoldDB; C6XY00; -.
DR   STRING; 485917.Phep_2214; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; phe:Phep_2214; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000852; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 2.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ACU04418.1};
KW   Hydrolase {ECO:0000313|EMBL:ACU04418.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000852};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..549
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002971941"
FT   DOMAIN          26..155
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          185..493
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   549 AA;  60836 MW;  43CD96DBBF5E11F6 CRC64;
     MKAIKRILNI SILCCLLPVI TVAQASQATQ KKYKIPVLKG RANNPVLRIK IELNEAAELQ
     QIDILTKGTL RLNDIQDVKL LASGTDSALF KAEKAGMLRL FAAANAPLKE KTSLTGNLPL
     QKGINYLWLT LSLKATANAA SFLNINATLV RLNKDSLKIT PDNYANRLGI ALRQHNQDQV
     HTYRIPGLAT ANDGTLLGIY DVRRDSGRDL QGNIDIGLSR SLDKGKTWQP MQIVMDMGTW
     GNLPEKFNGV SDANILVDKK TGHIFIAGLW MYGVINEQGK WLEGLTEQSK DWNHQWKTKG
     SQPGFEPKQT AQFLIVKSTD HGKTWSKPVN LTKMCKQEDW WLWAPAPGQG ITMKNGTLVF
     PTQGRNASGK AFSNLTYSSD GGHTWKTSRA ATQESTTENM VVELTDGTLM LNMRSNANSK
     DTSSTNGRAI AITNNMGQDW TLHPTSHQAL PEPTCMASII RHDFVQNGKK RSVLLFSNPD
     AKTARKNMTI KVSYDDGKTW SSDKKILLDE EKSRGYSCLT SIDNNTIGIL YEGSQADMVF
     QTIKLDELL
//