Skip Header

Contribute Send feedback
Read comments (?) or add your own

C6XXU9 (C6XXU9_PEDHD) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:Phep_2163
OrganismPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290) [Complete proteome] [HAMAP]
Taxonomic identifier485917 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Sphingobacteriaceae › Pedobacter ›

Protein attributes

Sequence length869 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1271O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
C6XXU9 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 1C62A069D7C438A7

FASTA86997,773
        10         20         30         40         50         60 
MAEDLENQEN DKIIRIDIDE QMRSAYIDYS MSVIVSRALP DVRDGLKPVH RRVLYGMLDL 

        70         80         90        100        110        120 
GLANNKPYKK SARIVGEVLG KYHPHGDASV YNTMVRMAQE WSLRYLMVEG QGNYGSIDGD 

       130        140        150        160        170        180 
SPAAMRYTEA RFQKIAEDML ADINKDTVDF QLNFDDSLQE PTVLPSKVPN LLINGSSGIA 

       190        200        210        220        230        240 
VGMATNMPPH NITETINATI AYIDNNEITI AELMKFIKAP DFPTGAIIYG YTGVQEAFET 

       250        260        270        280        290        300 
GRGRIVMRAK AEIEAAKDRE VIIVTEIPYQ VNKAQMIERT AELVGEKKLE GISNIKDESN 

       310        320        330        340        350        360 
KDGIRIVYEI KRDANASIVL NNLFKQTALQ TSFSVNNIAL VKGRPQLLNL RDLIHYFVEH 

       370        380        390        400        410        420 
RHEVVVRRTK FELAEAKKRA HILEGLLIAL DHLDEVIKLI RSSDTPEDAR TGLMEKFGLS 

       430        440        450        460        470        480 
DIQARAILDM TLRRLTGLER DKIKDEYNEL MKTIEYLQSI LDDESKRMQI IKDELTEMKE 

       490        500        510        520        530        540 
KYGDERRTTI VHSAEDMSME DFIEDEEVVI TISHEGYIKR TPATEYRTQG RGGKGSKGSD 

       550        560        570        580        590        600 
SRNEDFIEHL LIASNHNYML FFTETGRCFW LRVYEIPEGT RLSKGRAIQN IINIPKEEKI 

       610        620        630        640        650        660 
KAFIKVKNLK DQEYLENNYI IMCTKKGTIK KTSLEAYSRP RVNGINAINI NEGDQLLEAS 

       670        680        690        700        710        720 
LTTGSSEIVM ALRSGRAIRF NEEKVRPMGR TATGVRGVTL AHEKDEVVGM IAVDDPGATI 

       730        740        750        760        770        780 
LVVSEKGYGK RTDIEDYRVT NRGGKGVKTI NVTDKTGNLV AIKSVTDADD LMIINKSGIV 

       790        800        810        820        830        840 
IRIVVSELRV MGRATQGVRL INLKGNDEIA SVARIEHEDE EVEEAESHVV VDGEPAGEVE 

       850        860 
EEITEEPTAE EENEEEGDAD EDASEEEDN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001681 Genomic DNA. Translation: ACU04367.1.
RefSeqYP_003092429.1. NC_013061.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING485917.Phep_2163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU04367; ACU04367; Phep_2163.
GeneID8253269.
KEGGphe:Phep_2163.
PATRIC22881397. VBIPedHep98714_2176.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.

Enzyme and pathway databases

BioCycPHEP485917:GHL9-2186-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6XXU9_PEDHD
AccessionPrimary (citable) accession number: C6XXU9
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 29, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info