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C6XVI9 (C6XVI9_PEDHD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Phep_1847 EMBL ACU04055.1
OrganismPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290) [Complete proteome] [HAMAP] EMBL ACU04055.1
Taxonomic identifier485917 [NCBI]
Taxonomic lineageBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaePedobacter

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain124 – 324201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding150 – 20556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2771Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2911Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2911Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2931Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C6XVI9 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 4036ED18894C7EBF

FASTA32836,187
        10         20         30         40         50         60 
MKKKIALLTG GTTGEWVVSV KSAATIAQNL DADKFDVYKI MLTQQGWFYE PADSVKIEVD 

        70         80         90        100        110        120 
RNDFSINLKG KKVKFEGVFI AIHGSPGEDG KLQGYFDMLG IPYTTCDALT SAVTMNKGYT 

       130        140        150        160        170        180 
KAIVDGIAEL NIAKSAQIFK GTPYSLEQIK KTLKVPYFVK PNNGGSSIGM SKVNHPDDLQ 

       190        200        210        220        230        240 
AAIDRAFKED SQILIEEFIS GREFTIGVVK LDGEITVLPA TEVETAKEFF DFEAKYTPGV 

       250        260        270        280        290        300 
ATETTPAPIR KETLERVTQI VKNVYLKLNC RGVVRIDFIL NGDEGDFYFI EINTIPGQTA 

       310        320 
TSFIPQQVAA AGMKLNDFYT KLIRETIG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001681 Genomic DNA. Translation: ACU04055.1.
RefSeqYP_003092117.1. NC_013061.1.

3D structure databases

ProteinModelPortalC6XVI9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485917.Phep_1847.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU04055; ACU04055; Phep_1847.
GeneID8252951.
KEGGphe:Phep_1847.
PATRIC22880773. VBIPedHep98714_1866.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycPHEP485917:GHL9-1868-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6XVI9_PEDHD
AccessionPrimary (citable) accession number: C6XVI9
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)