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C6XTP1 (C6XTP1_PEDHD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Phep_1463
OrganismPedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290) [Complete proteome] [HAMAP]
Taxonomic identifier485917 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Sphingobacteriaceae › Pedobacter

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region126 – 13495-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1301Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
C6XTP1 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 7CC3DDE6C9085AF2

FASTA22124,364
        10         20         30         40         50         60 
MYNKSDIELK VAEFLLQIKA IKLQPANPFT WASGWKSPIY CDNRVTLSHP SVRTYIRQKL 

        70         80         90        100        110        120 
SQLIQEEFGS VDLIAGVATA GIPQGALVAQ ELGLPFAYVR AKAKEHGTGS LIEGEIVEGQ 

       130        140        150        160        170        180 
RVVVIEDLIS TGKSSLQAVE ALRKAGLSVA GLVAIFTYGF DQADENFAAA KCRYATLSNY 

       190        200        210        220 
NTLIEYAAEH SFIAQKDVDL LTKWRRNPAE WGKELEELNN S

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001681 Genomic DNA. Translation: ACU03677.1.
RefSeqYP_003091739.1. NC_013061.1.

3D structure databases

ProteinModelPortalC6XTP1.
ModBaseSearch...

Protein-protein interaction databases

STRINGC6XTP1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8252564.
GenomeReviewsGene locus Phep_1463 in contig CP001681_GR.
KEGGphe:Phep_1463.
PATRIC22880005. VBIPedHep98714_1485.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALPMTYVR.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6XTP1_PEDHD
AccessionPrimary (citable) accession number: C6XTP1
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info