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C6XRV5 (C6XRV5_HIRBI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00116
Short name=dUTPase HAMAP-Rule MF_00116
EC=3.6.1.23 HAMAP-Rule MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP-Rule MF_00116
Gene names
Name:dut HAMAP-Rule MF_00116
Ordered Locus Names:Hbal_3047 EMBL ACT60715.1
OrganismHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418) [Complete proteome] [HAMAP] EMBL ACT60715.1
Taxonomic identifier582402 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hirschia ›

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP-Rule MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP-Rule MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP-Rule MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region75 – 773Substrate binding By similarity HAMAP-Rule MF_00116
Region92 – 943Substrate binding By similarity HAMAP-Rule MF_00116

Sites

Binding site881Substrate By similarity HAMAP-Rule MF_00116
Binding site1021Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00116

Sequences

Sequence LengthMass (Da)Tools
C6XRV5 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: ABD5CA4AC917779B

FASTA15516,472
        10         20         30         40         50         60 
MSQPANTAII EVKPLPHFEG LALPAYETTS AAGMDLRAAN NEGEDIVLAP MARDMIPTGL 

        70         80         90        100        110        120 
SMAIPHGYEV QIRPRSGLAA KHGITCLNTP GTIDADYRGE VKVILINLGS EPFTIKRGER 

       130        140        150 
IAQMVVAPVT QGVWKEVDEL SSTDRGTGGF GSTGR

« Hide

References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49814 / DSM 5838 / IFAM 1418.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001678 Genomic DNA. Translation: ACT60715.1.
RefSeqYP_003061412.1. NC_012982.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING582402.Hbal_3047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT60715; ACT60715; Hbal_3047.
GeneID8184313.
KEGGhba:Hbal_3047.
PATRIC22134254. VBIHirBal9878_3132.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHOG000028968.
KOK01520.
OMACLINLSN.
ProtClustDBCLSK2531856.

Enzyme and pathway databases

BioCycHBAL582402:GHMV-3161-MONOMER.
UniPathwayUPA00610; UER00666.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6XRV5_HIRBI
AccessionPrimary (citable) accession number: C6XRV5
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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