C6XRD7 (C6XRD7_HIRBI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
Short name=CMK HAMAP MF_00061
EC=2.7.1.148 HAMAP MF_00061

Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP MF_00061

Gene names

Name:	ispE HAMAP MF_00061
Ordered Locus Names:	Hbal_1075

Organism

Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418) [Complete proteome] [HAMAP]

Taxonomic identifier

582402 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hirschia

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061
Catalytic activity	ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061
Sequence similarities	Belongs to the GHMP kinase family. IspE subfamily. HAMAP MF_00061

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00061
Ligand	ATP-binding HAMAP MF_00061 RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00061 RuleBase RU003563 EMBL ACT58769.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	104 – 114	11	ATP By similarity HAMAP MF_00061
Sites
	Active site	16	1	By similarity HAMAP MF_00061
	Active site	146	1	By similarity HAMAP MF_00061

Sequences

	Sequence		Length	Mass (Da)
	C6XRD7 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 4931EAED6E52391C	FASTA	299	31,730
	10 20 30 40 50 60 MIDRATSLST VWAPAKVNLY LHVGKPLPDG RHPLDSLVMF ADGNAADRVS VRPYQTVVLK 70 80 90 100 110 120 VDGPAAKALK GEKNNLVLRA AKLLMDAAGR SDLGAALNLH KELPVAAGIG GGSADAAATL 130 140 150 160 170 180 QALNHYWDIG FGDQAILNLG AELGADVPAC LQSEPVLMRG IGEQLTPFKM QPLPIVLVNP 190 200 210 220 230 240 NVPLSTADVF KKFDAMGLGS DFKEREGPDS SGGPEVLARS LERYSNDLEV PAKILCPAVK 250 260 270 280 290 DVLDTIEKTE GALMARMSGS GPTCFGVFET MEAAQAAAYI ISKRKKKWWV KASLLSGSR

References

[1]

"Genome sequences of eight morphologically diverse alphaproteobacteria." US DOE Joint Genome Institute Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V. J. Bacteriol. 193:4567-4568(2011) [PubMed: 21705585] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49814 / DSM 5838 / IFAM 1418.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001678 Genomic DNA. Translation: ACT58769.1.
RefSeq	YP_003059466.1. NC_012982.1.
3D structure databases
ProteinModelPortal	C6XRD7.
ModBase	Search...
Protein-protein interaction databases
STRING	C6XRD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8186643.
GenomeReviews	Gene locus Hbal_1075 in contig CP001678_GR.
KEGG	hba:Hbal_1075.
PATRIC	22130140. VBIHirBal9878_1107.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CQLARMS.
Family and domain databases
HAMAP	MF_00061. IspE. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00919.
PANTHER	PTHR20861:SF2. IspE. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF010376. IspE. 1 hit.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00154. IspE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6XRD7_HIRBI

Accession

Primary (citable) accession number: C6XRD7

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)