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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHBAL582402:GHMV-2386-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Ordered Locus Names:Hbal_2343
OrganismiHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)
Taxonomic identifieri582402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHirschia
Proteomesi
  • UP000002745 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003897561 – 346Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST346

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi582402.Hbal_2343.

Structurei

3D structure databases

SMRiC6XMV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 292CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
HOGENOMiHOG000021670.
KOiK01963.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

C6XMV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWLTNLPPG LKNVFGKKDT PENLWIKCPK SGDLVYKDDL EASLFVTPAG
60 70 80 90 100
AHLRVGPDLR FKSMFDGSEY EELELPEVVK DPLKFKDDRK YVDRLKSSRA
110 120 130 140 150
KTGREDCMAA AIGKIGKQNA VVLVQDFAFM GGSLGMAAGE AFITAAEKAL
160 170 180 190 200
ETKSALIICT ASGGARMQEG ALSLMQMPRT TVAITELKDA SLPYIVVLTD
210 220 230 240 250
PTTGGVAASY AMIGDIHIGE PEAMVAFAGA RVIEQTIREK LPEGFQRAEF
260 270 280 290 300
LRERGMVDMV VDRRDLPAKL GQILSMLMGG KPLPEVEPIA VADVEELEAA
310 320 330 340
EAEAAPDEVV EVEAPAVDEI VEEKPAATKA KPRSKAKSKA APKTDE
Length:346
Mass (Da):37,320
Last modified:September 22, 2009 - v1
Checksum:i6F7C6B6F06E3FFAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001678 Genomic DNA. Translation: ACT60023.1.
RefSeqiWP_015828173.1. NC_012982.1.

Genome annotation databases

EnsemblBacteriaiACT60023; ACT60023; Hbal_2343.
KEGGihba:Hbal_2343.

Similar proteinsi

Entry informationi

Entry nameiACCD_HIRBI
AccessioniPrimary (citable) accession number: C6XMV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 22, 2009
Last modified: June 7, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families