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C6XMG2 (C6XMG2_HIRBI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Hbal_0403 EMBL ACT58105.1
OrganismHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418) [Complete proteome] [HAMAP] EMBL ACT58105.1
Taxonomic identifier582402 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHirschia

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 296197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding127 – 18155ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2491Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2651Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C6XMG2 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: D2BB285A12900E00

FASTA30232,632
        10         20         30         40         50         60 
MNRVAVIMGG WSSEREVSLS SGRGMAQAAR NEGFDVVEID ITRDLSNQLK EANPDVVLNA 

        70         80         90        100        110        120 
LHGPYGEDGC VQGLLEILEI PYSHSGVLAS ALAMDKAKSR NVYARMGLLV AEGGVYAKED 

       130        140        150        160        170        180 
VAAEHVMKPP YVVKPIAEGS SFGVLIVPEG ANRPPAELLD PKWGFGDSVL VEQFIPGREL 

       190        200        210        220        230        240 
TVSVMGNEAL AVTEITTLRD YYDYSAKYEA GGSKHVIPAE ISDAVTQAAL DAALIAHDAL 

       250        260        270        280        290        300 
GCRGVSRSDF RYDDDTKRLV ILETNTQPGM TPTSLVPEQA AHKGISYEKL VRWMIEDASC 


HR 

« Hide

References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49814 / DSM 5838 / IFAM 1418.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001678 Genomic DNA. Translation: ACT58105.1.
RefSeqYP_003058802.1. NC_012982.1.

3D structure databases

ProteinModelPortalC6XMG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING582402.Hbal_0403.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT58105; ACT58105; Hbal_0403.
GeneID8186529.
KEGGhba:Hbal_0403.
PATRIC22128736. VBIHirBal9878_0413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycHBAL582402:GHMV-407-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6XMG2_HIRBI
AccessionPrimary (citable) accession number: C6XMG2
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)