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C6XJ15 (C6XJ15_HIRBI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:Hbal_1419 EMBL ACT59110.1
OrganismHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418) [Complete proteome] [HAMAP] EMBL ACT59110.1
Taxonomic identifier582402 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hirschia ›

Protein attributes

Sequence length981 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1571O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
C6XJ15 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: E7106B74C760C55A

FASTA981107,836
        10         20         30         40         50         60 
MSDETENPEN ENPENGLDAA NGEAGGPDDP QLPVRFDAGE DGVSPINISD EMKKSYLDYA 

        70         80         90        100        110        120 
MSVIVSRALP DVRDGLKPVH RRILFSMSEQ GYTFDKAYKK SARVVGDVIG KYHPHGDQSV 

       130        140        150        160        170        180 
YDALVRMAQN FSMGLPLLDG QGNFGSMDGD PAAAMRYTEV KLKKVANHLL ADIDKDTVNF 

       190        200        210        220        230        240 
QENYDGSEKE PIVLPARFPN LLVNGGGGIA VGMATNIPPH NLGEVIDATI AMIEDPNIDD 

       250        260        270        280        290        300 
EALLEIVPGP DFPTGALIIG RAGSRSGLMT GRGSVIMRSK SSIEELKNGR EALVFTEIPY 

       310        320        330        340        350        360 
QVNKASMIEK IAELVRDKRI EGIADMRDES DRDGVRVVVE VKRDASPEVV LNQLFRYTQL 

       370        380        390        400        410        420 
QTSFGMNMLA LNSGRPELLS LKAILQAFII FREEVVARRT KFELNKARAR AHLLVGLALA 

       430        440        450        460        470        480 
VANIDEVIKI IRHSPDPSTA REKLMDRAWP AQDMLSLINL IADRRTVANE VGEIRLSEEQ 

       490        500        510        520        530        540 
ARAILDLRLQ RLTGLGRDEI GDEARGLADR IADYLDILSS RPRVMEIITE ELRVVREEFA 

       550        560        570        580        590        600 
IPRRSQFIEA ELDMDDEAFI EKEDMVVMFT HGGYAKRTAL SIYRTQHRGG RGRSGMGTKE 

       610        620        630        640        650        660 
EDAVTRFFVA NTHTEVLFFS STGMVYKTKV WRMPLGTPQS RGKALVNLLP LDKGETITSV 

       670        680        690        700        710        720 
MPLPEDEEER ANMNILFATR SGGVRRNKLS DFTQVNRNGK IAMKLDEAQV AGSDDGIVGV 

       730        740        750        760        770        780 
QICSPDDDVM LTTALGQCIR FKVEDVRVFT GRTSTGVRGI RLANGDEVIS MLVLRHMDIT 

       790        800        810        820        830        840 
SPEARAYLKH ASAMRRALGE EEGDTEIDVV SEPDADDEGD EAALSPERIA ELGAAEEFLL 

       850        860        870        880        890        900 
TITEDGMGKR ASAYDYRVTG RGGKGLIAHK LNAGRRLAAA FPIEDGDEIM LVTDAGQLIR 

       910        920        930        940        950        960 
TPAKQIRIAG RATQGVKVLR TSGEERVVSV ERLAEQESDV DENETEENVD GSAEIVDVAI 

       970        980 
DGAPEGEPNS ETNDSSNDQQ E

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References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49814 / DSM 5838 / IFAM 1418.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001678 Genomic DNA. Translation: ACT59110.1.
RefSeqYP_003059807.1. NC_012982.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING582402.Hbal_1419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT59110; ACT59110; Hbal_1419.
GeneID8185982.
KEGGhba:Hbal_1419.
PATRIC22130860. VBIHirBal9878_1462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAAAIEPMR.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycHBAL582402:GHMV-1505-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6XJ15_HIRBI
AccessionPrimary (citable) accession number: C6XJ15
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info