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C6XJ10

- C6XJ10_HIRBI

UniProt

C6XJ10 - C6XJ10_HIRBI

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

Cofactori

FAD.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 266FADUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotation

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein

Enzyme and pathway databases

BioCyciHBAL582402:GHMV-1432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Hbal_1414Imported
OrganismiHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)Imported
Taxonomic identifieri582402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHirschia
ProteomesiUP000002745: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi582402.Hbal_1414.

Structurei

3D structure databases

ProteinModelPortaliC6XJ10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

C6XJ10 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQLDNDANQ KSTLAPIHVI GGGMAGCEAA WQAANLGVPV ILHEMRPTKK
60 70 80 90 100
TEAHQTDGLA ELVCSNSFRS DDFENNAVGL LHEEMRRANG LIISTAHDHQ
110 120 130 140 150
IPAGSALAVD RDGFSQAVTA KIQAHPLITI EREEVPGIPP AEWDSVIIAT
160 170 180 190 200
GPLTSPSMGE AIKELTGEDE LSFFDAIAPI VYYDSIDMSK AWRQSRYDKP
210 220 230 240 250
GPSGETDAYV NCPMNEEQYL AFLEALNNAP KTEFKEWEKD TPYFEGCLPV
260 270 280 290 300
EVMASRGPET LRYGPLKPVG LTNAHQPDVK AHAIVQLRQD NKLGTLWNIV
310 320 330 340 350
GFQTKMTYGA QKDVLRMIPG LENAEFARLG GIHRNTFINS PKVLNNKLQL
360 370 380 390 400
KNQLRIRFAG QVSGVEGYVE SAAMGLLAGR FAAFERLGRE ISPPPETTAL
410 420 430 440 450
GSLISHVTGG HLIGKATFQP MNVNFGLFPD IDFAKADPET GKRYRGKDKS
460 470
RAKKRAQSAR ALKDIQEWLG TQS
Length:473
Mass (Da):51,831
Last modified:September 22, 2009 - v1
Checksum:iE7CC48318D4ADC3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001678 Genomic DNA. Translation: ACT59105.1.
RefSeqiWP_015827255.1. NC_012982.1.
YP_003059802.1. NC_012982.1.

Genome annotation databases

EnsemblBacteriaiACT59105; ACT59105; Hbal_1414.
GeneIDi8185977.
KEGGihba:Hbal_1414.
PATRICi22130848. VBIHirBal9878_1456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001678 Genomic DNA. Translation: ACT59105.1 .
RefSeqi WP_015827255.1. NC_012982.1.
YP_003059802.1. NC_012982.1.

3D structure databases

ProteinModelPortali C6XJ10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 582402.Hbal_1414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT59105 ; ACT59105 ; Hbal_1414 .
GeneIDi 8185977.
KEGGi hba:Hbal_1414.
PATRICi 22130848. VBIHirBal9878_1456.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci HBAL582402:GHMV-1432-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49814 / DSM 5838 / IFAM 1418Imported.

Entry informationi

Entry nameiC6XJ10_HIRBI
AccessioniPrimary (citable) accession number: C6XJ10
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3