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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 26FADUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processtRNA processingUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein

Enzyme and pathway databases

BioCyciHBAL582402:GHMV-1432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Hbal_1414Imported
OrganismiHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)Imported
Taxonomic identifieri582402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHirschia
Proteomesi
  • UP000002745 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi582402.Hbal_1414.

Structurei

3D structure databases

ProteinModelPortaliC6XJ10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
KOiK04094.
OMAiRFGPMKP.
OrthoDBiPOG091H00B3.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
PANTHERiPTHR11806. PTHR11806. 1 hit.
PTHR11806:SF5. PTHR11806:SF5. 1 hit.
PfamiView protein in Pfam
PF01134. GIDA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

C6XJ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLDNDANQ KSTLAPIHVI GGGMAGCEAA WQAANLGVPV ILHEMRPTKK
60 70 80 90 100
TEAHQTDGLA ELVCSNSFRS DDFENNAVGL LHEEMRRANG LIISTAHDHQ
110 120 130 140 150
IPAGSALAVD RDGFSQAVTA KIQAHPLITI EREEVPGIPP AEWDSVIIAT
160 170 180 190 200
GPLTSPSMGE AIKELTGEDE LSFFDAIAPI VYYDSIDMSK AWRQSRYDKP
210 220 230 240 250
GPSGETDAYV NCPMNEEQYL AFLEALNNAP KTEFKEWEKD TPYFEGCLPV
260 270 280 290 300
EVMASRGPET LRYGPLKPVG LTNAHQPDVK AHAIVQLRQD NKLGTLWNIV
310 320 330 340 350
GFQTKMTYGA QKDVLRMIPG LENAEFARLG GIHRNTFINS PKVLNNKLQL
360 370 380 390 400
KNQLRIRFAG QVSGVEGYVE SAAMGLLAGR FAAFERLGRE ISPPPETTAL
410 420 430 440 450
GSLISHVTGG HLIGKATFQP MNVNFGLFPD IDFAKADPET GKRYRGKDKS
460 470
RAKKRAQSAR ALKDIQEWLG TQS
Length:473
Mass (Da):51,831
Last modified:September 22, 2009 - v1
Checksum:iE7CC48318D4ADC3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001678 Genomic DNA. Translation: ACT59105.1.
RefSeqiWP_015827255.1. NC_012982.1.

Genome annotation databases

EnsemblBacteriaiACT59105; ACT59105; Hbal_1414.
KEGGihba:Hbal_1414.

Similar proteinsi

Entry informationi

Entry nameiC6XJ10_HIRBI
AccessioniPrimary (citable) accession number: C6XJ10
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported