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C6XJ10

- C6XJ10_HIRBI

UniProt

C6XJ10 - C6XJ10_HIRBI

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 266FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciHBAL582402:GHMV-1432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:Hbal_1414Imported
    OrganismiHirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)Imported
    Taxonomic identifieri582402 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHirschia
    ProteomesiUP000002745: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi582402.Hbal_1414.

    Structurei

    3D structure databases

    ProteinModelPortaliC6XJ10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6XJ10-1 [UniParc]FASTAAdd to Basket

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    MTQLDNDANQ KSTLAPIHVI GGGMAGCEAA WQAANLGVPV ILHEMRPTKK    50
    TEAHQTDGLA ELVCSNSFRS DDFENNAVGL LHEEMRRANG LIISTAHDHQ 100
    IPAGSALAVD RDGFSQAVTA KIQAHPLITI EREEVPGIPP AEWDSVIIAT 150
    GPLTSPSMGE AIKELTGEDE LSFFDAIAPI VYYDSIDMSK AWRQSRYDKP 200
    GPSGETDAYV NCPMNEEQYL AFLEALNNAP KTEFKEWEKD TPYFEGCLPV 250
    EVMASRGPET LRYGPLKPVG LTNAHQPDVK AHAIVQLRQD NKLGTLWNIV 300
    GFQTKMTYGA QKDVLRMIPG LENAEFARLG GIHRNTFINS PKVLNNKLQL 350
    KNQLRIRFAG QVSGVEGYVE SAAMGLLAGR FAAFERLGRE ISPPPETTAL 400
    GSLISHVTGG HLIGKATFQP MNVNFGLFPD IDFAKADPET GKRYRGKDKS 450
    RAKKRAQSAR ALKDIQEWLG TQS 473
    Length:473
    Mass (Da):51,831
    Last modified:September 22, 2009 - v1
    Checksum:iE7CC48318D4ADC3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001678 Genomic DNA. Translation: ACT59105.1.
    RefSeqiWP_015827255.1. NC_012982.1.
    YP_003059802.1. NC_012982.1.

    Genome annotation databases

    EnsemblBacteriaiACT59105; ACT59105; Hbal_1414.
    GeneIDi8185977.
    KEGGihba:Hbal_1414.
    PATRICi22130848. VBIHirBal9878_1456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001678 Genomic DNA. Translation: ACT59105.1 .
    RefSeqi WP_015827255.1. NC_012982.1.
    YP_003059802.1. NC_012982.1.

    3D structure databases

    ProteinModelPortali C6XJ10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 582402.Hbal_1414.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT59105 ; ACT59105 ; Hbal_1414 .
    GeneIDi 8185977.
    KEGGi hba:Hbal_1414.
    PATRICi 22130848. VBIHirBal9878_1456.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci HBAL582402:GHMV-1432-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49814 / DSM 5838 / IFAM 1418Imported.

    Entry informationi

    Entry nameiC6XJ10_HIRBI
    AccessioniPrimary (citable) accession number: C6XJ10
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3