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C6XG72

- C6XG72_LIBAP

UniProt

C6XG72 - C6XG72_LIBAP

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Protein
Isocitrate dehydrogenase [NADP]
Gene
CLIBASIA_04005
Organism
Liberibacter asiaticus (strain psy62)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarity
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarity
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLASI537021:GHEM-831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:CLIBASIA_04005Imported
OrganismiLiberibacter asiaticus (strain psy62)Imported
Taxonomic identifieri537021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter
ProteomesiUP000002744: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi537021.CLIBASIA_04005.

Structurei

3D structure databases

ProteinModelPortaliC6XG72.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6XG72-1 [UniParc]FASTAAdd to Basket

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MKKIKVTKPV VSLDGDEMTR IIWQLIQENL IHPYLDIKIE YFDLSIQNRD    50
LTDDQVTIDA AHAIKNCGVG IKCATITADQ ARVKEFNLKK MWKSPNGTIR 100
NILGGIIFRE PIICSNVPRL IPGWKKPIII GRHAFGDQYR ATDFQFPSKG 150
KLILKFVGDD GQTIEKEVFD SPGSGIAMAM YNLDDSIRNF ARAAMQYALA 200
RQLPLYLSTK DTILKSYDGR FKNIFNEIFE AEFKNQFDEL GITYTHRLID 250
DMVASSIKWS GGYIWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT 300
METEAAHGTV TRHYRQHQQG KETSTNSIAS IFAWTRGLLH RAKLDENAEL 350
KKFAENLERV CIKTVEDGFM TKDLALLIGP EQDWLSTTDF IEKISDNLRD 400
ALQKNLSISD KQ 412
Length:412
Mass (Da):46,577
Last modified:September 22, 2009 - v1
Checksum:i65D6307019BC3244
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001677 Genomic DNA. Translation: ACT57375.1.
RefSeqiWP_015452733.1. NC_012985.3.
YP_003065315.1. NC_012985.3.

Genome annotation databases

EnsemblBacteriaiACT57375; ACT57375; CLIBASIA_04005.
GeneIDi8209922.
KEGGilas:CLIBASIA_04005.
PATRICi31988746. VBICanLib64949_0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001677 Genomic DNA. Translation: ACT57375.1 .
RefSeqi WP_015452733.1. NC_012985.3.
YP_003065315.1. NC_012985.3.

3D structure databases

ProteinModelPortali C6XG72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 537021.CLIBASIA_04005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT57375 ; ACT57375 ; CLIBASIA_04005 .
GeneIDi 8209922.
KEGGi las:CLIBASIA_04005.
PATRICi 31988746. VBICanLib64949_0822.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci LASI537021:GHEM-831-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics."
    Duan Y., Zhou L., Hall D.G., Li W., Doddapaneni H., Lin H., Liu L., Vahling C.M., Gabriel D.W., Williams K.P., Dickerman A., Sun Y., Gottwald T.
    Mol. Plant Microbe Interact. 22:1011-1020(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: psy62.

Entry informationi

Entry nameiC6XG72_LIBAP
AccessioniPrimary (citable) accession number: C6XG72
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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