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C6XG72

- C6XG72_LIBAP

UniProt

C6XG72 - C6XG72_LIBAP

Protein

Isocitrate dehydrogenase [NADP]

Gene

CLIBASIA_04005

Organism
Liberibacter asiaticus (strain psy62)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091Substrate
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciLASI537021:GHEM-831-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:CLIBASIA_04005Imported
    OrganismiLiberibacter asiaticus (strain psy62)Imported
    Taxonomic identifieri537021 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter
    ProteomesiUP000002744: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi537021.CLIBASIA_04005.

    Structurei

    3D structure databases

    ProteinModelPortaliC6XG72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6XG72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKVTKPV VSLDGDEMTR IIWQLIQENL IHPYLDIKIE YFDLSIQNRD    50
    LTDDQVTIDA AHAIKNCGVG IKCATITADQ ARVKEFNLKK MWKSPNGTIR 100
    NILGGIIFRE PIICSNVPRL IPGWKKPIII GRHAFGDQYR ATDFQFPSKG 150
    KLILKFVGDD GQTIEKEVFD SPGSGIAMAM YNLDDSIRNF ARAAMQYALA 200
    RQLPLYLSTK DTILKSYDGR FKNIFNEIFE AEFKNQFDEL GITYTHRLID 250
    DMVASSIKWS GGYIWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT 300
    METEAAHGTV TRHYRQHQQG KETSTNSIAS IFAWTRGLLH RAKLDENAEL 350
    KKFAENLERV CIKTVEDGFM TKDLALLIGP EQDWLSTTDF IEKISDNLRD 400
    ALQKNLSISD KQ 412
    Length:412
    Mass (Da):46,577
    Last modified:September 22, 2009 - v1
    Checksum:i65D6307019BC3244
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001677 Genomic DNA. Translation: ACT57375.1.
    RefSeqiWP_015452733.1. NC_012985.3.
    YP_003065315.1. NC_012985.3.

    Genome annotation databases

    EnsemblBacteriaiACT57375; ACT57375; CLIBASIA_04005.
    GeneIDi8209922.
    KEGGilas:CLIBASIA_04005.
    PATRICi31988746. VBICanLib64949_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001677 Genomic DNA. Translation: ACT57375.1 .
    RefSeqi WP_015452733.1. NC_012985.3.
    YP_003065315.1. NC_012985.3.

    3D structure databases

    ProteinModelPortali C6XG72.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 537021.CLIBASIA_04005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT57375 ; ACT57375 ; CLIBASIA_04005 .
    GeneIDi 8209922.
    KEGGi las:CLIBASIA_04005.
    PATRICi 31988746. VBICanLib64949_0822.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci LASI537021:GHEM-831-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics."
      Duan Y., Zhou L., Hall D.G., Li W., Doddapaneni H., Lin H., Liu L., Vahling C.M., Gabriel D.W., Williams K.P., Dickerman A., Sun Y., Gottwald T.
      Mol. Plant Microbe Interact. 22:1011-1020(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Psy62Imported.
    2. "Diversity and plasticity of the intracellular plant pathogen and insect symbiont, 'Candidatus Liberibacter asiaticus', revealed by hyper variable prophage genes with intragenic tandem repeats."
      Zhou L., Powell C.A., Hoffman M.T., Li W., Fan G., Liu B., Lin H., Duan Y.
      Appl. Environ. Microbiol. 77:6663-6673(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: psy62Imported.

    Entry informationi

    Entry nameiC6XG72_LIBAP
    AccessioniPrimary (citable) accession number: C6XG72
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3