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C6XG72

- C6XG72_LIBAP

UniProt

C6XG72 - C6XG72_LIBAP

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Protein

Isocitrate dehydrogenase [NADP]

Gene

CLIBASIA_04005

Organism
Liberibacter asiaticus (strain psy62)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821NADPUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLASI537021:GHEM-831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:CLIBASIA_04005Imported
OrganismiLiberibacter asiaticus (strain psy62)Imported
Taxonomic identifieri537021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter
ProteomesiUP000002744: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi537021.CLIBASIA_04005.

Structurei

3D structure databases

ProteinModelPortaliC6XG72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6XG72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIKVTKPV VSLDGDEMTR IIWQLIQENL IHPYLDIKIE YFDLSIQNRD
60 70 80 90 100
LTDDQVTIDA AHAIKNCGVG IKCATITADQ ARVKEFNLKK MWKSPNGTIR
110 120 130 140 150
NILGGIIFRE PIICSNVPRL IPGWKKPIII GRHAFGDQYR ATDFQFPSKG
160 170 180 190 200
KLILKFVGDD GQTIEKEVFD SPGSGIAMAM YNLDDSIRNF ARAAMQYALA
210 220 230 240 250
RQLPLYLSTK DTILKSYDGR FKNIFNEIFE AEFKNQFDEL GITYTHRLID
260 270 280 290 300
DMVASSIKWS GGYIWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT
310 320 330 340 350
METEAAHGTV TRHYRQHQQG KETSTNSIAS IFAWTRGLLH RAKLDENAEL
360 370 380 390 400
KKFAENLERV CIKTVEDGFM TKDLALLIGP EQDWLSTTDF IEKISDNLRD
410
ALQKNLSISD KQ
Length:412
Mass (Da):46,577
Last modified:September 22, 2009 - v1
Checksum:i65D6307019BC3244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001677 Genomic DNA. Translation: ACT57375.1.
RefSeqiYP_003065315.1. NC_012985.3.

Genome annotation databases

EnsemblBacteriaiACT57375; ACT57375; CLIBASIA_04005.
GeneIDi8209922.
KEGGilas:CLIBASIA_04005.
PATRICi31988746. VBICanLib64949_0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001677 Genomic DNA. Translation: ACT57375.1 .
RefSeqi YP_003065315.1. NC_012985.3.

3D structure databases

ProteinModelPortali C6XG72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 537021.CLIBASIA_04005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT57375 ; ACT57375 ; CLIBASIA_04005 .
GeneIDi 8209922.
KEGGi las:CLIBASIA_04005.
PATRICi 31988746. VBICanLib64949_0822.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci LASI537021:GHEM-831-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics."
    Duan Y., Zhou L., Hall D.G., Li W., Doddapaneni H., Lin H., Liu L., Vahling C.M., Gabriel D.W., Williams K.P., Dickerman A., Sun Y., Gottwald T.
    Mol. Plant Microbe Interact. 22:1011-1020(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Psy62Imported.
  2. "Diversity and plasticity of the intracellular plant pathogen and insect symbiont, 'Candidatus Liberibacter asiaticus', revealed by hyper variable prophage genes with intragenic tandem repeats."
    Zhou L., Powell C.A., Hoffman M.T., Li W., Fan G., Liu B., Lin H., Duan Y.
    Appl. Environ. Microbiol. 77:6663-6673(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: psy62Imported.

Entry informationi

Entry nameiC6XG72_LIBAP
AccessioniPrimary (citable) accession number: C6XG72
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3