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C6XG72 (C6XG72_LIBAP) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:CLIBASIA_04005 EMBL ACT57375.1
OrganismLiberibacter asiaticus (strain psy62) [Complete proteome] [HAMAP] EMBL ACT57375.1
Taxonomic identifier537021 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity
Metal binding2731Magnesium or manganese By similarity
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
C6XG72 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 65D6307019BC3244

FASTA41246,577
        10         20         30         40         50         60 
MKKIKVTKPV VSLDGDEMTR IIWQLIQENL IHPYLDIKIE YFDLSIQNRD LTDDQVTIDA 

        70         80         90        100        110        120 
AHAIKNCGVG IKCATITADQ ARVKEFNLKK MWKSPNGTIR NILGGIIFRE PIICSNVPRL 

       130        140        150        160        170        180 
IPGWKKPIII GRHAFGDQYR ATDFQFPSKG KLILKFVGDD GQTIEKEVFD SPGSGIAMAM 

       190        200        210        220        230        240 
YNLDDSIRNF ARAAMQYALA RQLPLYLSTK DTILKSYDGR FKNIFNEIFE AEFKNQFDEL 

       250        260        270        280        290        300 
GITYTHRLID DMVASSIKWS GGYIWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT 

       310        320        330        340        350        360 
METEAAHGTV TRHYRQHQQG KETSTNSIAS IFAWTRGLLH RAKLDENAEL KKFAENLERV 

       370        380        390        400        410 
CIKTVEDGFM TKDLALLIGP EQDWLSTTDF IEKISDNLRD ALQKNLSISD KQ 

« Hide

References

[1]"Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics."
Duan Y., Zhou L., Hall D.G., Li W., Doddapaneni H., Lin H., Liu L., Vahling C.M., Gabriel D.W., Williams K.P., Dickerman A., Sun Y., Gottwald T.
Mol. Plant Microbe Interact. 22:1011-1020(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: psy62.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001677 Genomic DNA. Translation: ACT57375.1.
RefSeqYP_003065315.1. NC_012985.3.

3D structure databases

ProteinModelPortalC6XG72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING537021.CLIBASIA_04005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT57375; ACT57375; CLIBASIA_04005.
GeneID8209922.
KEGGlas:CLIBASIA_04005.
PATRIC31988746. VBICanLib64949_0822.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycLASI537021:GHEM-831-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6XG72_LIBAP
AccessionPrimary (citable) accession number: C6XG72
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)