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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Liberibacter asiaticus (strain psy62)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, HelicaseUniRule annotationImported, Hydrolase
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repair, SOS responseUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotationImported
Ordered Locus Names:CLIBASIA_02200Imported
OrganismiLiberibacter asiaticus (strain psy62)Imported
Taxonomic identifieri537021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter
Proteomesi
  • UP000002744 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi537021.CLIBASIA_02200.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 62RuvA_NInterPro annotationAdd BLAST62
Domaini163 – 206RuvA_CInterPro annotationAdd BLAST44

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057115.
KOiK03550.
OMAiKSAGRIM.
OrthoDBiPOG091H02EF.

Family and domain databases

CDDicd14332. UBA_RuvA_C. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA. 1 hit.
InterProiView protein in InterPro
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
IPR011114. RuvA_C.
PANTHERiPTHR33796. PTHR33796. 1 hit.
PfamiView protein in Pfam
PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

C6XF74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKIKGNIE GLYEDYVLID VQGVCYIIYC PIRTLSCLGK IGDFCTLFVE
60 70 80 90 100
THMRQDQIRL FGFLSDLDRQ WFMLLQSVQG VGARVAMGVL SRITATELVE
110 120 130 140 150
SIILQNSKVI AQIPGISMKI ASRIMTELKG KAISLSSVVQ QDMSCVNKEQ
160 170 180 190 200
AHICSMPSFA INAISALVNL GYGQDQATTA VVSVLKKEKN IADDSQIIRL

ALRAISC
Length:207
Mass (Da):22,737
Last modified:September 22, 2009 - v1
Checksum:i3567EF9BB9066D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001677 Genomic DNA. Translation: ACT57026.1.
RefSeqiWP_015452605.1. NC_012985.3.

Genome annotation databases

EnsemblBacteriaiACT57026; ACT57026; CLIBASIA_02200.
KEGGilas:CLIBASIA_02200.
PATRICi31988452. VBICanLib64949_0693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001677 Genomic DNA. Translation: ACT57026.1.
RefSeqiWP_015452605.1. NC_012985.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi537021.CLIBASIA_02200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT57026; ACT57026; CLIBASIA_02200.
KEGGilas:CLIBASIA_02200.
PATRICi31988452. VBICanLib64949_0693.

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057115.
KOiK03550.
OMAiKSAGRIM.
OrthoDBiPOG091H02EF.

Family and domain databases

CDDicd14332. UBA_RuvA_C. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA. 1 hit.
InterProiView protein in InterPro
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
IPR011114. RuvA_C.
PANTHERiPTHR33796. PTHR33796. 1 hit.
PfamiView protein in Pfam
PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC6XF74_LIBAP
AccessioniPrimary (citable) accession number: C6XF74
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 12, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.