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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Methylovorus glucosetrophus (strain SIP3-4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711UniRule annotation
Active sitei609 – 6091UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMGLU582744:GHXQ-1472-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Msip34_1435Imported
OrganismiMethylovorus glucosetrophus (strain SIP3-4)Imported
Taxonomic identifieri582744 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
ProteomesiUP000002743: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi582744.Msip34_1435.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6XDQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRLLLHQGK PQKGMNNVLM VIGEHGMTSR IYSHNEKLLR ENIRYLGRVL
60 70 80 90 100
GEVIKSKEGE ETFDRIEAIR TAAVNFHRHG NTKAAKSLEK LLKTLTVEQA
110 120 130 140 150
IPVIRAFSYF KHLVNIAEDL HAHQQSRLVE DQAAPGMLTH SLQKLAASDL
160 170 180 190 200
DAAEIGDFFA NALISPVLTA HPTEVQRKSI LDTERALSLL LVEKSNVVSI
210 220 230 240 250
REAERNERMI VGAITTLWQT RILRFSKLTV ANEIENALSY YRMTFLQVIP
260 270 280 290 300
ELMQDFENDL RHVFADKLSP EYKLPSFLQM GSWIGGDRDG NPFVNGATLE
310 320 330 340 350
QAIIQQSATA FAYYLEQVEA LRSELSLSTR LVGVTPALVK LAQASGEQSL
360 370 380 390 400
HRQDETYRLA LNGIHARLAQ TAKLLVNERG DVRREISAIP YTSAEALLAD
410 420 430 440 450
MNVIAESLQS QQGEALIYPR LGKLIKAIET FGFHLATVDL RQSSDVHELV
460 470 480 490 500
IKELFLKAGQ DFNYATLDED EKVEVLLEEL KQPRLLFSPF QQYSELVQSE
510 520 530 540 550
MEVLQKARGI RAGYGKRAIR QYIISHTETL SDLLEVALLQ KETGMLRGVW
560 570 580 590 600
GSAKVQMDLN IVPLFETIAD LRHAPMIMGQ WLSLLGIRHL LRYQGNEQEI
610 620 630 640 650
MLGYSDSNKD GGFITSNWEL YKAEISLVEL FRQANIRLRL FHGRGGTVGR
660 670 680 690 700
GGGPTYQAIM AQPQGTVDGQ IRLTEQGEII ANKYSEPRVG RQHLETLVAA
710 720 730 740 750
TIDGSLFPPD PLLAKKRRSF EIIMEELSAT AMTAYRTLVY ETAGFAEYFF
760 770 780 790 800
NATPISEIAE LNIGSRPASR KATQRIEDLR AIPWGFSWGQ CRLLLPGWFG
810 820 830 840 850
VGSAIHEYLF IEDKLQPARL KTLHDMLEQW PLFRSLISNV DMVLAKTDLA
860 870 880 890 900
VAQRYSMLVP DKKLREGIFA AIEHEYQLTT EALNLLLNST ERLSSNPALA
910 920 930 940 950
NSIQNRLPYL DPLNHLQVEL IRQYRQGATN DRVKLAIHLT INGIAAGLRN

TG
Length:952
Mass (Da):107,133
Last modified:September 22, 2009 - v1
Checksum:i536E76A5B1D0E272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001674 Genomic DNA. Translation: ACT50680.1.
RefSeqiWP_015830127.1. NC_012969.1.
YP_003051207.1. NC_012969.1.

Genome annotation databases

EnsemblBacteriaiACT50680; ACT50680; Msip34_1435.
GeneIDi8173918.
KEGGimei:Msip34_1435.
PATRICi22617912. VBIMetSp110381_1444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001674 Genomic DNA. Translation: ACT50680.1.
RefSeqiWP_015830127.1. NC_012969.1.
YP_003051207.1. NC_012969.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi582744.Msip34_1435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT50680; ACT50680; Msip34_1435.
GeneIDi8173918.
KEGGimei:Msip34_1435.
PATRICi22617912. VBIMetSp110381_1444.

Phylogenomic databases

eggNOGiCOG2352.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMGLU582744:GHXQ-1472-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methylovorus sp. SIP3-4."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SIP3-4Imported.

Entry informationi

Entry nameiC6XDQ5_METGS
AccessioniPrimary (citable) accession number: C6XDQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.