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C6XDK8

- C6XDK8_METGS

UniProt

C6XDK8 - C6XDK8_METGS

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Methylovorus glucosetrophus (strain SIP3-4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131UniRule annotation
Active sitei244 – 2441UniRule annotation
Active sitei274 – 2741UniRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMGLU582744:GHXQ-1424-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
Beta-ketoacyl-ACP synthase IIIUniRule annotation
Gene namesi
Name:fabHUniRule annotation
Ordered Locus Names:Msip34_1388Imported
OrganismiMethylovorus glucosetrophus (strain SIP3-4)Imported
Taxonomic identifieri582744 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
ProteomesiUP000002743: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi582744.Msip34_1388.

Structurei

3D structure databases

ProteinModelPortaliC6XDK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni245 – 2495ACP-bindingUniRule annotation

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0332.
KOiK00648.
OMAiAHIVEET.
OrthoDBiEOG6J74XN.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

C6XDK8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYSRIAGTG SYLPERILTN AELERMVDTS DEWIVTRTGI RERHIAAEGQ
60 70 80 90 100
FTSDLAYEAA LRAIEAAGIT HEEIDLVIVA TTTPDRVFPS TACLVQARLG
110 120 130 140 150
LGPCPAFDIQ AVCSGFVYAL ATADNFIKSG AAKTALVIGA ETMSRITDWT
160 170 180 190 200
DRSNCILWGD GAGAVILRAS DEMGILSTHL HADGQYARLL NVPTGVSQKE
210 220 230 240 250
GSKTIHMEGN AVFKVAVNTL DAIVDETLEA NGLQKSDVDW LVPHQANIRI
260 270 280 290 300
LQSTAKKLGM GMEKVVVTVD RHGNTSAASI PLALDVAVRD GRIKRGETLL
310
MEAFGGGFTW GSVLVKF
Length:317
Mass (Da):34,033
Last modified:September 22, 2009 - v1
Checksum:iB9E8C6A81C90D768
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001674 Genomic DNA. Translation: ACT50633.1.
RefSeqiWP_015830094.1. NC_012969.1.
YP_003051160.1. NC_012969.1.

Genome annotation databases

EnsemblBacteriaiACT50633; ACT50633; Msip34_1388.
GeneIDi8173870.
KEGGimei:Msip34_1388.
PATRICi22617816. VBIMetSp110381_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001674 Genomic DNA. Translation: ACT50633.1 .
RefSeqi WP_015830094.1. NC_012969.1.
YP_003051160.1. NC_012969.1.

3D structure databases

ProteinModelPortali C6XDK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 582744.Msip34_1388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT50633 ; ACT50633 ; Msip34_1388 .
GeneIDi 8173870.
KEGGi mei:Msip34_1388.
PATRICi 22617816. VBIMetSp110381_1397.

Phylogenomic databases

eggNOGi COG0332.
KOi K00648.
OMAi AHIVEET.
OrthoDBi EOG6J74XN.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MGLU582744:GHXQ-1424-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
HAMAPi MF_01815. FabH.
InterProi IPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 1 hit.
TIGRFAMsi TIGR00747. fabH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylovorus sp. SIP3-4."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SIP3-4Imported.

Entry informationi

Entry nameiC6XDK8_METGS
AccessioniPrimary (citable) accession number: C6XDK8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

External Data

Dasty 3