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C6XDK8

- C6XDK8_METGS

UniProt

C6XDK8 - C6XDK8_METGS

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Methylovorus glucosetrophus (strain SIP3-4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei113 – 1131UniRule annotation
    Active sitei244 – 2441UniRule annotation
    Active sitei274 – 2741UniRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
    2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMGLU582744:GHXQ-1424-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
    Beta-ketoacyl-ACP synthase IIIUniRule annotation
    Gene namesi
    Name:fabHUniRule annotation
    Ordered Locus Names:Msip34_1388Imported
    OrganismiMethylovorus glucosetrophus (strain SIP3-4)Imported
    Taxonomic identifieri582744 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
    ProteomesiUP000002743: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi582744.Msip34_1388.

    Structurei

    3D structure databases

    ProteinModelPortaliC6XDK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni245 – 2495ACP-bindingUniRule annotation

    Domaini

    The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

    Sequence similaritiesi

    Belongs to the FabH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0332.
    KOiK00648.
    OMAiAHIVEET.
    OrthoDBiEOG6J74XN.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    HAMAPiMF_01815. FabH.
    InterProiIPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 1 hit.
    TIGRFAMsiTIGR00747. fabH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6XDK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYSRIAGTG SYLPERILTN AELERMVDTS DEWIVTRTGI RERHIAAEGQ    50
    FTSDLAYEAA LRAIEAAGIT HEEIDLVIVA TTTPDRVFPS TACLVQARLG 100
    LGPCPAFDIQ AVCSGFVYAL ATADNFIKSG AAKTALVIGA ETMSRITDWT 150
    DRSNCILWGD GAGAVILRAS DEMGILSTHL HADGQYARLL NVPTGVSQKE 200
    GSKTIHMEGN AVFKVAVNTL DAIVDETLEA NGLQKSDVDW LVPHQANIRI 250
    LQSTAKKLGM GMEKVVVTVD RHGNTSAASI PLALDVAVRD GRIKRGETLL 300
    MEAFGGGFTW GSVLVKF 317
    Length:317
    Mass (Da):34,033
    Last modified:September 22, 2009 - v1
    Checksum:iB9E8C6A81C90D768
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001674 Genomic DNA. Translation: ACT50633.1.
    RefSeqiYP_003051160.1. NC_012969.1.

    Genome annotation databases

    EnsemblBacteriaiACT50633; ACT50633; Msip34_1388.
    GeneIDi8173870.
    KEGGimei:Msip34_1388.
    PATRICi22617816. VBIMetSp110381_1397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001674 Genomic DNA. Translation: ACT50633.1 .
    RefSeqi YP_003051160.1. NC_012969.1.

    3D structure databases

    ProteinModelPortali C6XDK8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 582744.Msip34_1388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT50633 ; ACT50633 ; Msip34_1388 .
    GeneIDi 8173870.
    KEGGi mei:Msip34_1388.
    PATRICi 22617816. VBIMetSp110381_1397.

    Phylogenomic databases

    eggNOGi COG0332.
    KOi K00648.
    OMAi AHIVEET.
    OrthoDBi EOG6J74XN.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MGLU582744:GHXQ-1424-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    HAMAPi MF_01815. FabH.
    InterProi IPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 1 hit.
    TIGRFAMsi TIGR00747. fabH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylovorus sp. SIP3-4."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SIP3-4Imported.

    Entry informationi

    Entry nameiC6XDK8_METGS
    AccessioniPrimary (citable) accession number: C6XDK8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3