ID   C6XBR4_METGS            Unreviewed;       470 AA.
AC   C6XBR4;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Excinuclease cho {ECO:0000256|ARBA:ARBA00040756};
DE   AltName: Full=Endonuclease cho {ECO:0000256|ARBA:ARBA00042732};
DE   AltName: Full=UvrC homolog protein {ECO:0000256|ARBA:ARBA00042138};
GN   OrderedLocusNames=Msip34_2797 {ECO:0000313|EMBL:ACT52034.1};
OS   Methylovorus glucosotrophus (strain SIP3-4).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylovorus.
OX   NCBI_TaxID=582744 {ECO:0000313|EMBL:ACT52034.1, ECO:0000313|Proteomes:UP000002743};
RN   [1] {ECO:0000313|Proteomes:UP000002743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIP3-4 {ECO:0000313|Proteomes:UP000002743};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.;
RT   "Complete sequence of chromosome of Methylovorus sp. SIP3-4.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACT52034.1, ECO:0000313|Proteomes:UP000002743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIP3-4 {ECO:0000313|EMBL:ACT52034.1,
RC   ECO:0000313|Proteomes:UP000002743};
RX   PubMed=21622745; DOI=10.1128/JB.00404-11;
RA   Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA   Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA   Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT   "Genomes of three methylotrophs from a single niche uncover genetic and
RT   metabolic divergence of Methylophilaceae.";
RL   J. Bacteriol. 193:3757-3764(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001674; ACT52034.1; -; Genomic_DNA.
DR   RefSeq; WP_015831229.1; NC_012969.1.
DR   AlphaFoldDB; C6XBR4; -.
DR   STRING; 582744.Msip34_2797; -.
DR   KEGG; mei:Msip34_2797; -.
DR   eggNOG; COG0322; Bacteria.
DR   eggNOG; COG0847; Bacteria.
DR   HOGENOM; CLU_030720_0_0_4; -.
DR   OrthoDB; 9803913at2; -.
DR   Proteomes; UP000002743; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   CDD; cd06127; DEDDh; 1.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00573; dnaq; 1.
DR   PANTHER; PTHR30562:SF10; EXCINUCLEASE CHO; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:ACT52034.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002743};
KW   Transferase {ECO:0000313|EMBL:ACT52034.1}.
FT   DOMAIN          199..277
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
SQ   SEQUENCE   470 AA;  52663 MW;  39992B950CE3ED44 CRC64;
     MLPAYVLLDL ETTGATPLVD RITEIALIRF ENGQEVSRWQ TLVNPETAIP PFIQRLTGID
     DGMVATAPRF REVAGELLNH LEGAVLCAHN VRFDHGFLKN EFKRIGIDLR QKVLCTVKLS
     RKLYPQHRSH SLDSIIERHS LQCGARHRAM GDVVALVDFL RAAEAELGPV VIAQAARELL
     KGHTLPSGID ASILDDIPEG PGVYLFYGDN QLPLYIGKSI NIRSRVLSHF SGDHASTKEM
     RISQEVKHIE WIETAGEFSA LMLESRLVKE RQPIYNRRLR RERQLCSWRL AASHDARPLL
     TLVREEEIDP PELGQLFGTF RSKRQAVEVL RQIAENHALC PKVLGLESGK GPCFSHQLRK
     CKGVCAGKEA AELHYLRLQQ ALAAHRMKTW PYPGKIGIHE RNPLTGQSQL HVFEHWCALG
     SVDDEASLHS LASSKTSLMF DLDTYKLLLR ELAKASANIK CLVTGTTMVA
//