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C6XB59 (C6XB59_METSD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione synthetase HAMAP-Rule MF_00162
EC=6.3.2.3 HAMAP-Rule MF_00162
Alternative name(s):
GSH synthetase HAMAP-Rule MF_00162
Glutathione synthase HAMAP-Rule MF_00162
Gene names
Name:gshB HAMAP-Rule MF_00162
Ordered Locus Names:Msip34_2592 EMBL ACT51829.1
OrganismMethylovorus sp. (strain SIP3-4) (Methylotenera sp. (strain SIP3-4)) [Complete proteome] [HAMAP] EMBL ACT51829.1
Taxonomic identifier582744 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylovorus ›

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP-Rule MF_00162

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00162

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP-Rule MF_00162

Sequence similarities

Belongs to the prokaryotic GSH synthase family. HAMAP-Rule MF_00162

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 306186ATP-grasp By similarity HAMAP-Rule MF_00162
Nucleotide binding147 – 20357ATP By similarity HAMAP-Rule MF_00162

Sites

Metal binding2771Magnesium or manganese By similarity HAMAP-Rule MF_00162
Metal binding2791Magnesium or manganese By similarity HAMAP-Rule MF_00162

Sequences

Sequence LengthMass (Da)Tools
C6XB59 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: DEF4740A5B2319A6

FASTA31034,272
        10         20         30         40         50         60 
MQLLFILDPL DKLVTYKDTS LAIMREAARR GHALAVCEQQ QVLLRHDKVT VQYRDFAFGE 

        70         80         90        100        110        120 
HGYVLGDLQE TAPEQFDAVL MRKDPPFDNE FLYSTYLLEI AERQGARILN APQAVRGWNE 

       130        140        150        160        170        180 
KLSITRFPQF APPFLVTRQR TLIREFLAAH GDIVVKPLDG MGGSSVFRLT QQDPNIGVIL 

       190        200        210        220        230        240 
ETITDFEKRT VMAQRYLPEI VKGDKRILII NGEPVPYALA RIPQNGETRG NLAAGGKGVA 

       250        260        270        280        290        300 
QALTERDREI ATTVGKVLKA NGLFLVGLDV IGDSLTEVNV TSPTGMVEIA AQTDCNPAAL 

       310 
MVDALETLSP

« Hide

References

[1]"Complete sequence of chromosome of Methylovorus sp. SIP3-4."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SIP3-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001674 Genomic DNA. Translation: ACT51829.1.
RefSeqYP_003052356.1. NC_012969.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING582744.Msip34_2592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT51829; ACT51829; Msip34_2592.
GeneID8174606.
KEGGmei:Msip34_2592.
PATRIC22620080. VBIMetSp110381_2511.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0189.
KOK01920.
OMAWMRKDPP.
ProtClustDBCLSK2529829.

Enzyme and pathway databases

BioCycMGLU582744:GHXQ-2739-MONOMER.
UniPathwayUPA00142; UER00210.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00162. GSH_S.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01380. glut_syn. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6XB59_METSD
AccessionPrimary (citable) accession number: C6XB59
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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