C6X9S4 (C6X9S4_METSD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP-Rule MF_01401
EC=1.8.4.11 HAMAP-Rule MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP-Rule MF_01401

Gene names

Name:	msrA HAMAP-Rule MF_01401
Ordered Locus Names:	Msip34_0646 EMBL ACT49894.1

Organism

Methylovorus sp. (strain SIP3-4) (Methylotenera sp. (strain SIP3-4)) [Complete proteome] [HAMAP] EMBL ACT49894.1

Taxonomic identifier

582744 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylovorus › Methylovorus glucosotrophus

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP-Rule MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_01401 SAAS SAAS002569 EMBL ACT49894.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	14	1	By similarity HAMAP-Rule MF_01401

Sequences

	Sequence		Length	Mass (Da)
	C6X9S4 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 2960C96C0DA11CCB	FASTA	180	20,281
	10 20 30 40 50 60 MVKELDVAVL AGGCFWCLEP VFSQLDGVEK VVSGYTGGHT LQPDYKQVCR GDTGHAEAIR 70 80 90 100 110 120 ISFDPARISF YELLEIFFLS HDPTTPNRQG NDIGTQYRSA IFCQNAAQRS TAEQMIAELN 130 140 150 160 170 180 QLHVFASPIV TEVNDAAVFY AAEDYHQQYY EQHQEQPYCM LVAAPKVAKI RAKFPEKIRN

References

[1]

"Complete sequence of chromosome of Methylovorus sp. SIP3-4." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L. Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SIP3-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001674 Genomic DNA. Translation: ACT49894.1.
RefSeq	YP_003050421.1. NC_012969.1.
3D structure databases
ProteinModelPortal	C6X9S4.
ModBase	Search...
Protein-protein interaction databases
STRING	582744.Msip34_0646.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT49894; ACT49894; Msip34_0646.
GeneID	8172540.
KEGG	mei:Msip34_0646.
PATRIC	22616298. VBIMetSp110381_0653.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
KO	K07304.
OMA	YCLAVIP.
ProtClustDB	CLSK2529646.
Enzyme and pathway databases
BioCyc	MGLU582744:GHXQ-758-MONOMER.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6X9S4_METSD

Accession

Primary (citable) accession number: C6X9S4

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)