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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Methylovorus glucosetrophus (strain SIP3-4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathway: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (Msip34_1878), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMGLU582744:GHXQ-641-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:Msip34_0627Imported
OrganismiMethylovorus glucosetrophus (strain SIP3-4)Imported
Taxonomic identifieri582744 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
ProteomesiUP000002743 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi582744.Msip34_0627.

Structurei

3D structure databases

ProteinModelPortaliC6X9Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0540.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6X9Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNPQLTPDG KLRHLLSTEG LPRAILNQIL DTAESFVGVA EREVKKVPLL
60 70 80 90 100
RGKTVCNIFF ENSTRTRTTF EIAAKRLSAD VINLNVNTSS QSKGETILDT
110 120 130 140 150
IDNLTAMHAD MFVIRHAQSG AAHLIAQHVA PHIHVINAGD GRHAHPTQGL
160 170 180 190 200
LDVFTIRRYK PDMHNLRVAL VGDVLHSRVA RSEIHALTTL GVPEVRVIAP
210 220 230 240 250
KTLLPQHVEK LGVQVYHDMR EGLKDVDVIM MLRLQNERMS GALLPSAQEY
260 270 280 290 300
FKCYGLTPEK LALAKPDAIV MHPGPMNRGV EIDSAVADGK QSVILPQVTY
310
GIAVRMAVMS MLAGNSA
Length:317
Mass (Da):34,776
Last modified:September 22, 2009 - v1
Checksum:i6D8CFDB00B7035A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001674 Genomic DNA. Translation: ACT49875.1.
RefSeqiWP_013441458.1. NC_012969.1.
YP_003050402.1. NC_012969.1.

Genome annotation databases

EnsemblBacteriaiACT49875; ACT49875; Msip34_0627.
KEGGimei:Msip34_0627.
PATRICi22616250. VBIMetSp110381_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001674 Genomic DNA. Translation: ACT49875.1.
RefSeqiWP_013441458.1. NC_012969.1.
YP_003050402.1. NC_012969.1.

3D structure databases

ProteinModelPortaliC6X9Q5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi582744.Msip34_0627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT49875; ACT49875; Msip34_0627.
KEGGimei:Msip34_0627.
PATRICi22616250. VBIMetSp110381_0635.

Phylogenomic databases

eggNOGiCOG0540.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciMGLU582744:GHXQ-641-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methylovorus sp. SIP3-4."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SIP3-4Imported.

Entry informationi

Entry nameiC6X9Q5_METGS
AccessioniPrimary (citable) accession number: C6X9Q5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 27, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.