ID   C6X4W8_FLAB3            Unreviewed;       635 AA.
AC   C6X4W8;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   OrderedLocusNames=FIC_01006 {ECO:0000313|EMBL:ACU07456.1};
OS   Flavobacteriaceae bacterium (strain 3519-10).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae.
OX   NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU07456.1, ECO:0000313|Proteomes:UP000001512};
RN   [1] {ECO:0000313|EMBL:ACU07456.1, ECO:0000313|Proteomes:UP000001512}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3519-10 {ECO:0000313|EMBL:ACU07456.1,
RC   ECO:0000313|Proteomes:UP000001512};
RX   PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA   Raymond J.A., Christner B.C., Schuster S.C.;
RT   "A bacterial ice-binding protein from the Vostok ice core.";
RL   Extremophiles 12:713-717(2008).
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DR   EMBL; CP001673; ACU07456.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6X4W8; -.
DR   STRING; 531844.FIC_01006; -.
DR   KEGG; fba:FIC_01006; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_3_6_10; -.
DR   OrthoDB; 9778383at2; -.
DR   Proteomes; UP000001512; Chromosome.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACU07456.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001512}.
FT   DOMAIN          12..68
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          70..462
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          519..598
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   635 AA;  72104 MW;  D98C36886450CB42 CRC64;
     MKNYFIDDLP DYFKQYKKSI KNPKKFWDKV ADENFVWYQR WSKVVEYDMQ EAKIKWFKNA
     KLNITKNCID RHLNTRGDKT AIIWEPNDPK EEAQHISYSE LRDRVCKMAN VLRDMGIEKG
     DRVCIYLPMI PELAVTMLAC ARLGAVHSVI FAGFSASAVT SRVNDCEAKL IICSDGSYRG
     HKAIDLKGII DEAVESCPTV EKVLVVKRTG GDVKMKDGRD FWLEPLYEKA ASDFISVIMD
     AEDPLFILYT SGSTGKPKGM LHTTAGYMVY TAYTFKNVFN YQENDIYWCT ADIGWITGHS
     YILYGPLANG ATTVIFEGVP TYPEPDRFWE VIEKHKVTQF YTAPTAIRSL AKESYEWVEK
     HDLSSLRVIG SVGEPINDEA WHWYNDHVGK KKCPIVDTWW QTETGGIMIS PIPFVTPTKP
     TYATLPLPGI QPVLMDDKRN EITGNQVDGN LCIRFPWPGI ARTIWGDHQR YKETYFTAFP
     GKYFTGDGAL RDEVGYYRIT GRVDDVIIVS GHNLGTAPIE DSINQHPAVA ESAIVGYPHD
     IKGSALYGYV ILKDVGESRD RENLRKEINQ VISDTVGPIA KLDKIQFVSA LPKTRSGKIM
     RRILRKIAEG DFANFGDIST LLNPEIVEEI KEERI
//