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C6WYI4 (C6WYI4_METML) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Mmol_2001 EMBL ACT48903.1
OrganismMethylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540) [Complete proteome] [HAMAP] EMBL ACT48903.1
Taxonomic identifier583345 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylotenera

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 296196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding127 – 18256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2501Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2651Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C6WYI4 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 81B34D91D7D9FA4D

FASTA30132,179
        10         20         30         40         50         60 
MQDFGKVAVL LGGKSGEREV SLKSGTAVLA ALQRQGVDAH AFDPATRPLH DLESFDTAMI 

        70         80         90        100        110        120 
SLHGRFGEDG AMQGALELLG IPYTGSGVMA SAIGMDKWRT KMMWSAAGVS TPAFELVSAD 

       130        140        150        160        170        180 
SDFEAIEQRL GLPLFVKPAN EGSSIGISKV KQTGGLKAAY ELAAKSDPLV IAEQFVGGGE 

       190        200        210        220        230        240 
YTVGILGDQA LPIVRIVPKN EFYDFEAKYL RDDTEYRCPC GLSAEKEAQI QQEALLAFNT 

       250        260        270        280        290        300 
IGCQGWGRVD FLMDEAGKHY FLEVNTSPGM TDHSLVPMAA KAAGISFDEL VVSVLRLAHV 


G 

« Hide

References

[1]"Complete sequence of Methylotenera mobilis JLW8."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JLW8 / ATCC BAA-1282 / DSM 17540.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001672 Genomic DNA. Translation: ACT48903.1.
RefSeqYP_003049430.1. NC_012968.1.

3D structure databases

ProteinModelPortalC6WYI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING583345.Mmol_2001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT48903; ACT48903; Mmol_2001.
GeneID8171273.
KEGGmmb:Mmol_2001.
PATRIC22614249. VBIMetMob89187_2015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycMMOB583345:GHCF-2054-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6WYI4_METML
AccessionPrimary (citable) accession number: C6WYI4
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)