ID C6WTB9_METML Unreviewed; 396 AA. AC C6WTB9; DT 22-SEP-2009, integrated into UniProtKB/TrEMBL. DT 22-SEP-2009, sequence version 1. DT 27-MAR-2024, entry version 86. DE RecName: Full=Elongation factor Tu {ECO:0000256|ARBA:ARBA00029554, ECO:0000256|HAMAP-Rule:MF_00118}; DE Short=EF-Tu {ECO:0000256|HAMAP-Rule:MF_00118}; GN Name=tuf {ECO:0000256|HAMAP-Rule:MF_00118}; GN OrderedLocusNames=Mmol_0331 {ECO:0000313|EMBL:ACT47241.1}, Mmol_0343 GN {ECO:0000313|EMBL:ACT47253.1}; OS Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540). OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales; OC Methylophilaceae; Methylotenera. OX NCBI_TaxID=583345 {ECO:0000313|EMBL:ACT47241.1, ECO:0000313|Proteomes:UP000002742}; RN [1] {ECO:0000313|Proteomes:UP000002742} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JLW8 / ATCC BAA-1282 / DSM 17540 RC {ECO:0000313|Proteomes:UP000002742}; RG US DOE Joint Genome Institute; RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., RA Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F., Land M., RA Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.; RT "Complete sequence of Methylotenera mobilis JLW8."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACT47241.1, ECO:0000313|Proteomes:UP000002742} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JLW8 {ECO:0000313|EMBL:ACT47241.1}, and JLW8 / ATCC BAA-1282 / RC DSM 17540 {ECO:0000313|Proteomes:UP000002742}; RX PubMed=21622745; DOI=10.1128/JB.00404-11; RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A., RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S., RA Lidstrom M.E., Ivanova N., Chistoserdova L.; RT "Genomes of three methylotrophs from a single niche uncover genetic and RT metabolic divergence of Methylophilaceae."; RL J. Bacteriol. 193:3757-3764(2011). CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl- CC tRNA to the A-site of ribosomes during protein biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A CC subfamily. {ECO:0000256|ARBA:ARBA00007249, ECO:0000256|HAMAP- CC Rule:MF_00118}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001672; ACT47241.1; -; Genomic_DNA. DR EMBL; CP001672; ACT47253.1; -; Genomic_DNA. DR RefSeq; WP_015831283.1; NC_012968.1. DR AlphaFoldDB; C6WTB9; -. DR STRING; 583345.Mmol_0331; -. DR KEGG; mmb:Mmol_0331; -. DR KEGG; mmb:Mmol_0343; -. DR eggNOG; COG0050; Bacteria. DR HOGENOM; CLU_007265_0_0_4; -. DR OrthoDB; 9803139at2; -. DR Proteomes; UP000002742; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0097216; F:guanosine tetraphosphate binding; IEA:UniProt. DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule. DR CDD; cd01884; EF_Tu; 1. DR CDD; cd03697; EFTU_II; 1. DR CDD; cd03707; EFTU_III; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 2.40.30.10; Translation factors; 2. DR HAMAP; MF_00118_B; EF_Tu_B; 1. DR InterPro; IPR041709; EF-Tu_GTP-bd. DR InterPro; IPR004161; EFTu-like_2. DR InterPro; IPR033720; EFTU_2. DR InterPro; IPR031157; G_TR_CS. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR000795; T_Tr_GTP-bd_dom. DR InterPro; IPR009000; Transl_B-barrel_sf. DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C. DR InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org. DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C. DR NCBIfam; TIGR00485; EF-Tu; 1. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1. DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1. DR Pfam; PF00009; GTP_EFTU; 1. DR Pfam; PF03144; GTP_EFTU_D2; 1. DR Pfam; PF03143; GTP_EFTU_D3; 1. DR PRINTS; PR00315; ELONGATNFCT. DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF50447; Translation proteins; 1. DR PROSITE; PS00301; G_TR_1; 1. DR PROSITE; PS51722; G_TR_2; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}; KW Elongation factor {ECO:0000256|ARBA:ARBA00022768, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP- KW Rule:MF_00118}; Reference proteome {ECO:0000313|Proteomes:UP000002742}. FT DOMAIN 10..206 FT /note="Tr-type G" FT /evidence="ECO:0000259|PROSITE:PS51722" FT BINDING 19..26 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" FT BINDING 81..85 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" FT BINDING 136..139 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" SQ SEQUENCE 396 AA; 42726 MW; 6E8D45477106F660 CRC64; MAKGKFERTK PHVNVGTIGH VDHGKTTLTA AITTVLTKKF GGEAKAYDQI DAAPEEKARG ITINTAHVEY ETANRHYAHV DCPGHADYVK NMITGAAQMD GAILVCSAAD GPMPQTREHI LLARQVGVPY IVVFLNKADM VDDAELLELV EMEVRDLLSK YDFPGDDTPI VKGSAKLALE GDQSPIGEPA IFALADALDS YIPMPERAVD GTFLMPVEDV FSISGRGTVV TGRIERGIVK VGDEIEIVGL KDTLKTTCTG VEMFRKLLDQ GMAGDNVGVL LRGTKREEIE RGQVLAKAGS IKPHTKFTAE IYVLGKDEGG RHTPFFQGYR PQFYFRTTDV TGAVELPAGT EMVMPGDNVS ITVTLIAPIA MEEGLRFAIR EGGRTVGAGV VAKIIE //