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C6WSL1 (C6WSL1_ACTMD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Amir_7091 EMBL ACU40881.1
OrganismActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971) [Complete proteome] [HAMAP] EMBL ACU40881.1
Taxonomic identifier446462 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain102 – 309208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding136 – 19156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2631Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2781Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C6WSL1 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 13B4C0BE47F9E8C7

FASTA31433,043
        10         20         30         40         50         60 
MSNRWVAVLS GGLSHEREVS LRSGRRLTAA LRSAGLVVEE WDADGQLLSR LKEHRPDAVV 

        70         80         90        100        110        120 
VALHGGEGEN GSVQTILELA GVPFVGADSR ACRRAWDKPT AKGELSRAGL ATPEWAVLPH 

       130        140        150        160        170        180 
ATFRELGARP VLDSMIDRLG LPLMLKPAQG GSALGAQVVR DAADLPSAMV GCLAYGDTVL 

       190        200        210        220        230        240 
AERFVEGVEV AVAVVDGPDG PHALPPVEIV PESGVYDYTS RYTAGLTDFH APARLDEATA 

       250        260        270        280        290        300 
KAVGELAVSA HRLLGLRDVS RTDAIVEPDG TVHFLEVNVS PGLTETSTLP MAVEAAGTSL 

       310 
GEIYAALIER AVSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001630 Genomic DNA. Translation: ACU40881.1.
RefSeqYP_003104727.1. NC_013093.1.

3D structure databases

ProteinModelPortalC6WSL1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING446462.Amir_7091.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU40881; ACU40881; Amir_7091.
GeneID8331312.
KEGGami:Amir_7091.
PATRIC20777441. VBIActMir80567_7319.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADYTARYT.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycAMIR446462:GH7R-7167-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6WSL1_ACTMD
AccessionPrimary (citable) accession number: C6WSL1
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)