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C6WRG6

- C6WRG6_ACTMD

UniProt

C6WRG6 - C6WRG6_ACTMD

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Protein

Glycine--tRNA ligase

Gene
glyQS, Amir_1266
Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glycine to tRNA(Gly) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Substrate By similarityUniRule annotation
Binding sitei163 – 1631Substrate By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 1973ATP By similarityUniRule annotation
Nucleotide bindingi205 – 2106ATP By similarityUniRule annotation
Nucleotide bindingi282 – 2832ATP By similarityUniRule annotation
Nucleotide bindingi326 – 3294ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationsImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-1300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligaseUniRule annotation (EC:6.1.1.14UniRule annotation)
Alternative name(s):
Glycyl-tRNA synthetase
Gene namesi
Name:glyQSUniRule annotation
Ordered Locus Names:Amir_1266Imported
OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
Taxonomic identifieri446462 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema
ProteomesiUP000002213: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi446462.Amir_1266.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2145Substrate binding By similarityUniRule annotation
Regioni322 – 3265Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0423.
HOGENOMiHOG000242016.
KOiK01880.
OMAiMVYERDD.
OrthoDBiEOG6R87F8.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00253_B. Gly_tRNA_synth_B.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR022961. Gly_tRNA_ligase_bac.
IPR002315. tRNA-synt_gly.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01043. TRNASYNTHGLY.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00389. glyS_dimeric. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6WRG6-1 [UniParc]FASTAAdd to Basket

« Hide

MAVDRIETVV SLCKRRGFVY PCGEIYGGTR SAWDYGPLGV ELKDNIKRQW    50
WNFMVRGRED VVGLDSSVIL PREVWTASGH VEAFVDPLVE CNSCHKRFRQ 100
DTLSEEYAER TGKDVAEGDV SDVPCPNCGT RGQYTEPRMF NGLLKTHLGP 150
VETEEGLHYL RPETAQGIFT NFLNVQTTSR RKPPFGIGQI GKSFRNEITP 200
GNFIFRTREF EQMEMEFFVE PGTDEQWHQY WIDERTRWYT ELGISADNLR 250
HYEHPAEKLS HYAKRTVDIE YRFRFGGQEW GELEGIANRT DFDLTTHSNH 300
SGVDLSYFDQ ATNSRYRPFV IEPAAGVGRP MMAFLLEAYT EDEAPNAKGG 350
VDKRVVLRLD RRLAPVKAAV LPLSRNADLS PKAKDLAAAL RKHWNVEFDD 400
AGAIGRRYRR QDEIGTPFCV TVDFDTLTDH AVTVRERDTM SQERVSMDQI 450
EGYLAARLIG A 461
Length:461
Mass (Da):52,682
Last modified:September 22, 2009 - v1
Checksum:i7049E38ECC4E0AD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001630 Genomic DNA. Translation: ACU35218.1.
RefSeqiWP_015800108.1. NC_013093.1.
YP_003099064.1. NC_013093.1.

Genome annotation databases

EnsemblBacteriaiACU35218; ACU35218; Amir_1266.
GeneIDi8325443.
KEGGiami:Amir_1266.
PATRICi20765347. VBIActMir80567_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001630 Genomic DNA. Translation: ACU35218.1 .
RefSeqi WP_015800108.1. NC_013093.1.
YP_003099064.1. NC_013093.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 446462.Amir_1266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU35218 ; ACU35218 ; Amir_1266 .
GeneIDi 8325443.
KEGGi ami:Amir_1266.
PATRICi 20765347. VBIActMir80567_1290.

Phylogenomic databases

eggNOGi COG0423.
HOGENOMi HOG000242016.
KOi K01880.
OMAi MVYERDD.
OrthoDBi EOG6R87F8.

Enzyme and pathway databases

BioCyci AMIR446462:GH7R-1300-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00253_B. Gly_tRNA_synth_B.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR022961. Gly_tRNA_ligase_bac.
IPR002315. tRNA-synt_gly.
[Graphical view ]
PANTHERi PTHR10745. PTHR10745. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PRINTSi PR01043. TRNASYNTHGLY.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00389. glyS_dimeric. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971.

Entry informationi

Entry nameiC6WRG6_ACTMD
AccessioniPrimary (citable) accession number: C6WRG6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi