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C6WRG6

- C6WRG6_ACTMD

UniProt

C6WRG6 - C6WRG6_ACTMD

Protein

Glycine--tRNA ligase

Gene

glyQS

Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glycine to tRNA(Gly).UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991SubstrateUniRule annotation
    Binding sitei163 – 1631SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 1973ATPUniRule annotation
    Nucleotide bindingi205 – 2106ATPUniRule annotation
    Nucleotide bindingi282 – 2832ATPUniRule annotation
    Nucleotide bindingi326 – 3294ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMIR446462:GH7R-1300-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine--tRNA ligaseUniRule annotation (EC:6.1.1.14UniRule annotation)
    Alternative name(s):
    Glycyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:glyQSUniRule annotation
    Ordered Locus Names:Amir_1266Imported
    OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
    Taxonomic identifieri446462 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema
    ProteomesiUP000002213: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi446462.Amir_1266.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 2145Substrate bindingUniRule annotation
    Regioni322 – 3265Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0423.
    HOGENOMiHOG000242016.
    KOiK01880.
    OMAiMVYERDD.
    OrthoDBiEOG6R87F8.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00253_B. Gly_tRNA_synth_B.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR027031. Gly-tRNA_synthase/POLG2.
    IPR022961. Gly_tRNA_ligase_bac.
    IPR002315. tRNA-synt_gly.
    [Graphical view]
    PANTHERiPTHR10745. PTHR10745. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01043. TRNASYNTHGLY.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00389. glyS_dimeric. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6WRG6-1 [UniParc]FASTAAdd to Basket

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    MAVDRIETVV SLCKRRGFVY PCGEIYGGTR SAWDYGPLGV ELKDNIKRQW    50
    WNFMVRGRED VVGLDSSVIL PREVWTASGH VEAFVDPLVE CNSCHKRFRQ 100
    DTLSEEYAER TGKDVAEGDV SDVPCPNCGT RGQYTEPRMF NGLLKTHLGP 150
    VETEEGLHYL RPETAQGIFT NFLNVQTTSR RKPPFGIGQI GKSFRNEITP 200
    GNFIFRTREF EQMEMEFFVE PGTDEQWHQY WIDERTRWYT ELGISADNLR 250
    HYEHPAEKLS HYAKRTVDIE YRFRFGGQEW GELEGIANRT DFDLTTHSNH 300
    SGVDLSYFDQ ATNSRYRPFV IEPAAGVGRP MMAFLLEAYT EDEAPNAKGG 350
    VDKRVVLRLD RRLAPVKAAV LPLSRNADLS PKAKDLAAAL RKHWNVEFDD 400
    AGAIGRRYRR QDEIGTPFCV TVDFDTLTDH AVTVRERDTM SQERVSMDQI 450
    EGYLAARLIG A 461
    Length:461
    Mass (Da):52,682
    Last modified:September 22, 2009 - v1
    Checksum:i7049E38ECC4E0AD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001630 Genomic DNA. Translation: ACU35218.1.
    RefSeqiWP_015800108.1. NC_013093.1.
    YP_003099064.1. NC_013093.1.

    Genome annotation databases

    EnsemblBacteriaiACU35218; ACU35218; Amir_1266.
    GeneIDi8325443.
    KEGGiami:Amir_1266.
    PATRICi20765347. VBIActMir80567_1290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001630 Genomic DNA. Translation: ACU35218.1 .
    RefSeqi WP_015800108.1. NC_013093.1.
    YP_003099064.1. NC_013093.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 446462.Amir_1266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU35218 ; ACU35218 ; Amir_1266 .
    GeneIDi 8325443.
    KEGGi ami:Amir_1266.
    PATRICi 20765347. VBIActMir80567_1290.

    Phylogenomic databases

    eggNOGi COG0423.
    HOGENOMi HOG000242016.
    KOi K01880.
    OMAi MVYERDD.
    OrthoDBi EOG6R87F8.

    Enzyme and pathway databases

    BioCyci AMIR446462:GH7R-1300-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00253_B. Gly_tRNA_synth_B.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR027031. Gly-tRNA_synthase/POLG2.
    IPR022961. Gly_tRNA_ligase_bac.
    IPR002315. tRNA-synt_gly.
    [Graphical view ]
    PANTHERi PTHR10745. PTHR10745. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01043. TRNASYNTHGLY.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00389. glyS_dimeric. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971Imported.

    Entry informationi

    Entry nameiC6WRG6_ACTMD
    AccessioniPrimary (citable) accession number: C6WRG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3