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C6WRG6 (C6WRG6_ACTMD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine--tRNA ligase HAMAP-Rule MF_00253
EC=6.1.1.14 HAMAP-Rule MF_00253
Alternative name(s):
Glycyl-tRNA synthetase HAMAP-Rule MF_00253
Gene names
Name:glyQS HAMAP-Rule MF_00253
Ordered Locus Names:Amir_1266
OrganismActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971) [Complete proteome] [HAMAP]
Taxonomic identifier446462 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Actinosynnema ›

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glycine to tRNA(Gly) By similarity. HAMAP-Rule MF_00253 SAAS SAAS002315

Catalytic activity

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP-Rule MF_00253 SAAS SAAS022961

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00253 SAAS SAAS002315

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00253.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00253 RuleBase RU003746

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding195 – 1973ATP By similarity HAMAP-Rule MF_00253
Nucleotide binding205 – 2106ATP By similarity HAMAP-Rule MF_00253
Nucleotide binding282 – 2832ATP By similarity HAMAP-Rule MF_00253
Nucleotide binding326 – 3294ATP By similarity HAMAP-Rule MF_00253
Region210 – 2145Substrate binding By similarity HAMAP-Rule MF_00253
Region322 – 3265Substrate binding By similarity HAMAP-Rule MF_00253

Sites

Binding site991Substrate By similarity HAMAP-Rule MF_00253
Binding site1631Substrate By similarity HAMAP-Rule MF_00253

Sequences

Sequence LengthMass (Da)Tools
C6WRG6 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 7049E38ECC4E0AD0

FASTA46152,682
        10         20         30         40         50         60 
MAVDRIETVV SLCKRRGFVY PCGEIYGGTR SAWDYGPLGV ELKDNIKRQW WNFMVRGRED 

        70         80         90        100        110        120 
VVGLDSSVIL PREVWTASGH VEAFVDPLVE CNSCHKRFRQ DTLSEEYAER TGKDVAEGDV 

       130        140        150        160        170        180 
SDVPCPNCGT RGQYTEPRMF NGLLKTHLGP VETEEGLHYL RPETAQGIFT NFLNVQTTSR 

       190        200        210        220        230        240 
RKPPFGIGQI GKSFRNEITP GNFIFRTREF EQMEMEFFVE PGTDEQWHQY WIDERTRWYT 

       250        260        270        280        290        300 
ELGISADNLR HYEHPAEKLS HYAKRTVDIE YRFRFGGQEW GELEGIANRT DFDLTTHSNH 

       310        320        330        340        350        360 
SGVDLSYFDQ ATNSRYRPFV IEPAAGVGRP MMAFLLEAYT EDEAPNAKGG VDKRVVLRLD 

       370        380        390        400        410        420 
RRLAPVKAAV LPLSRNADLS PKAKDLAAAL RKHWNVEFDD AGAIGRRYRR QDEIGTPFCV 

       430        440        450        460 
TVDFDTLTDH AVTVRERDTM SQERVSMDQI EGYLAARLIG A

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001630 Genomic DNA. Translation: ACU35218.1.
RefSeqYP_003099064.1. NC_013093.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING446462.Amir_1266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU35218; ACU35218; Amir_1266.
GeneID8325443.
KEGGami:Amir_1266.
PATRIC20765347. VBIActMir80567_1290.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0423.
HOGENOMHOG000242016.
KOK01880.
OMADLSYFDQ.
ProtClustDBPRK04173.

Enzyme and pathway databases

BioCycAMIR446462:GH7R-1300-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00253_B. Gly_tRNA_synth_B.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR022961. Gly_tRNA_ligase_bac.
IPR002315. tRNA-synt_gly.
[Graphical view]
PANTHERPTHR10745. PTHR10745. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSPR01043. TRNASYNTHGLY.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00389. glyS_dimeric. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6WRG6_ACTMD
AccessionPrimary (citable) accession number: C6WRG6
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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