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Protein

Alpha-amylase

Gene

Amir_1130

Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. starch binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-1162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Amir_1130Imported
OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
Taxonomic identifieri446462 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema
ProteomesiUP000002213 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 PotentialImportedAdd
BLAST
Chaini25 – 566542 PotentialImportedPRO_5000498275Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi446462.Amir_1130.

Structurei

3D structure databases

ProteinModelPortaliC6WQ29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000253313.
KOiK01176.
OMAiGQNIFVV.
OrthoDBiEOG6RZB1B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR006048. A-amylase_b_C.
IPR006046. Alpha_amylase.
IPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF00686. CBM_20. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiSM00642. Aamy. 1 hit.
SM00632. Aamy_C. 1 hit.
SM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6WQ29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPARKIAL FAAGALIAGV VAAGATQLAS TPPTATATPP GAKTVTATLF
60 70 80 90 100
QWTFDRVATE CATTLGPKGY GYVEVSPATE HIQGGTWWTS YQPVSYRIAG
110 120 130 140 150
RLGSEAQFRN MVSACHNAGV KVIADAVINH MSAGSGTGTG GTRYTKYAYP
160 170 180 190 200
GHYGDQDFHT CRTDINDYRN RDNVQNCELS GLSDLNTGSE YVRSEIAEYL
210 220 230 240 250
NNLLSMGVDG FRIDAAKHMP AADLSAIKAK LTKRDAFWVH EVIYGAGEAV
260 270 280 290 300
QPGEYTGSGD VDEFRYAYDL KRVFTSENLA YLKNFGEGWG HLPSGQARPF
310 320 330 340 350
VDNWDTERNG STLSYKDGSN YTLANVFMLA WPYGSPQVYS GYEFSNKDQG
360 370 380 390 400
PPAPGECYSS GWECQHRWPQ IANMVGFRNT TSGTAVTNWW DNGRNAIAFG
410 420 430 440 450
RGDKGYAVVN RESSAVSRTF QTSLPAGTYC DVQRDGCTAT HVVNSAGQFT
460 470 480 490 500
ATVNANEAIA LHVGAMGNGS NPGAGAAAFS VNATTVMGQN IFVVGDHASL
510 520 530 540 550
GGWDPARAVA LSSASYPLWK TSVSLPNGTA FAYKYIRKEA NGSVTWESGA
560
NRTSTSPATL NDTWRN
Length:566
Mass (Da):60,650
Last modified:September 22, 2009 - v1
Checksum:i481AA7CC87358AAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001630 Genomic DNA. Translation: ACU35085.1.
RefSeqiYP_003098931.1. NC_013093.1.

Genome annotation databases

EnsemblBacteriaiACU35085; ACU35085; Amir_1130.
KEGGiami:Amir_1130.
PATRICi20765065. VBIActMir80567_1151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001630 Genomic DNA. Translation: ACU35085.1.
RefSeqiYP_003098931.1. NC_013093.1.

3D structure databases

ProteinModelPortaliC6WQ29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi446462.Amir_1130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU35085; ACU35085; Amir_1130.
KEGGiami:Amir_1130.
PATRICi20765065. VBIActMir80567_1151.

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000253313.
KOiK01176.
OMAiGQNIFVV.
OrthoDBiEOG6RZB1B.

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-1162-MONOMER.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR006048. A-amylase_b_C.
IPR006046. Alpha_amylase.
IPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF00686. CBM_20. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiSM00642. Aamy. 1 hit.
SM00632. Aamy_C. 1 hit.
SM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971Imported.

Entry informationi

Entry nameiC6WQ29_ACTMD
AccessioniPrimary (citable) accession number: C6WQ29
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: April 1, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.