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C6WKM8

- C6WKM8_ACTMD

UniProt

C6WKM8 - C6WKM8_ACTMD

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Protein

Isocitrate dehydrogenase [NADP]

Gene
Amir_6478
Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei212 – 2121Critical for catalysis By similarityUniRule annotation
Metal bindingi252 – 2521Magnesium or manganese By similarityUniRule annotation
Binding sitei260 – 2601NADP By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi310 – 3156NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-6544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Amir_6478Imported
OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
Taxonomic identifieri446462 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema
ProteomesiUP000002213: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi446462.Amir_6478.

Structurei

3D structure databases

ProteinModelPortaliC6WKM8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiFKDEFQR.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6WKM8-1 [UniParc]FASTAAdd to Basket

« Hide

MGKIKVQGTV VELDGDEMTR IIWQFIKDKL VHPYLDVNLE YYDLGIEHRD    50
ATDDQVTIDA ANAIKKHNVG VKCATITPDE ARVEEFGLKK MWVSPNGTIR 100
NILGGVVFRE PIIISNIPRL VPGWTKPIII GRHAHGDQYK ATNFKVPGAG 150
KLTVTFTPED GSAPIEHVVA NYGADGGVAM GMYNFNKSIE DFARASFSYG 200
LQRNYPVYMS TKNTILKAYD GAFKDIFQQV FEAEFKAEFD AKGLTYEHRL 250
IDDMVAAAMK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLMTPDG 300
KTVEAEAAHG TVTRHFRQHQ AGKPTSTNPI ASIFAWTGGL KHRGKLDGTP 350
EVTGFAETLE KVIIETVESG KMTKDLALLV GRDQEWQTTE DFLATLDENL 400
QKKMAG 406
Length:406
Mass (Da):44,879
Last modified:September 22, 2009 - v1
Checksum:iB0E3E0D3998AFE7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001630 Genomic DNA. Translation: ACU40279.1.
RefSeqiWP_015805162.1. NC_013093.1.
YP_003104125.1. NC_013093.1.

Genome annotation databases

EnsemblBacteriaiACU40279; ACU40279; Amir_6478.
GeneIDi8330689.
KEGGiami:Amir_6478.
PATRICi20776163. VBIActMir80567_6689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001630 Genomic DNA. Translation: ACU40279.1 .
RefSeqi WP_015805162.1. NC_013093.1.
YP_003104125.1. NC_013093.1.

3D structure databases

ProteinModelPortali C6WKM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 446462.Amir_6478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU40279 ; ACU40279 ; Amir_6478 .
GeneIDi 8330689.
KEGGi ami:Amir_6478.
PATRICi 20776163. VBIActMir80567_6689.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi FKDEFQR.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci AMIR446462:GH7R-6544-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971.

Entry informationi

Entry nameiC6WKM8_ACTMD
AccessioniPrimary (citable) accession number: C6WKM8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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