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C6WKM8 (C6WKM8_ACTMD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
C6WKM8 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: B0E3E0D3998AFE7A

FASTA40644,879
        10         20         30         40         50         60 
MGKIKVQGTV VELDGDEMTR IIWQFIKDKL VHPYLDVNLE YYDLGIEHRD ATDDQVTIDA 

        70         80         90        100        110        120 
ANAIKKHNVG VKCATITPDE ARVEEFGLKK MWVSPNGTIR NILGGVVFRE PIIISNIPRL 

       130        140        150        160        170        180 
VPGWTKPIII GRHAHGDQYK ATNFKVPGAG KLTVTFTPED GSAPIEHVVA NYGADGGVAM 

       190        200        210        220        230        240 
GMYNFNKSIE DFARASFSYG LQRNYPVYMS TKNTILKAYD GAFKDIFQQV FEAEFKAEFD 

       250        260        270        280        290        300 
AKGLTYEHRL IDDMVAAAMK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLMTPDG 

       310        320        330        340        350        360 
KTVEAEAAHG TVTRHFRQHQ AGKPTSTNPI ASIFAWTGGL KHRGKLDGTP EVTGFAETLE 

       370        380        390        400 
KVIIETVESG KMTKDLALLV GRDQEWQTTE DFLATLDENL QKKMAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001630 Genomic DNA. Translation: ACU40279.1.
RefSeqYP_003104125.1. NC_013093.1.

3D structure databases

ProteinModelPortalC6WKM8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING446462.Amir_6478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU40279; ACU40279; Amir_6478.
GeneID8330689.
KEGGami:Amir_6478.
PATRIC20776163. VBIActMir80567_6689.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAFKDEFQR.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycAMIR446462:GH7R-6544-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6WKM8_ACTMD
AccessionPrimary (citable) accession number: C6WKM8
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)