C6WIY1 (C6WIY1_ACTMD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
2-oxoglutarate dehydrogenase, E1 subunit EMBL ACU40057.1

Gene names

Ordered Locus Names:

Amir_6253

Organism

Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971) [Complete proteome] [HAMAP]

Taxonomic identifier

446462 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	1242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423

Ontologies

Keywords
Ligand	Thiamine pyrophosphate SAAS SAAS001017
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6WIY1 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 7E44297B5661761F	FASTA	1,242	136,304
	10 20 30 40 50 60 MSSSPASQFG PNEWLVEEMY EQFLADPSSV DPAWHDFFAD YKSTQRNGST TTAAPTAATQ 70 80 90 100 110 120 ADTGKAASSG APAAAKQAAS TAPAAKTPAA PAPSSAPKPK AAAPAKPAAA PAAKPAPAQA 130 140 150 160 170 180 AKAAPVQQAK GPEQKQLRGA AAAIAKNMEL SLTVPTATSV RAVPAKLLAD NRIVINNHLK 190 200 210 220 230 240 RTRGGKVSFT HLIGYAVVRA LQAFPNMNRH YAEINNKPHV VTPEHVNFGL AIDLPGKDGS 250 260 270 280 290 300 RTLVVASVKG CENMTFTQFW QAYEDLIRKA RGGSLTAEDF SGTTISLTNP GTIGTNHSVP 310 320 330 340 350 360 RLTAGQGTIV GVGAMEYPAH FQGTSEQALT DMGVSKIITL TSTYDHRIIQ GAESGEFLKR 370 380 390 400 410 420 VHQLLLGEDG FYDDVFTSLR LPYEPIRWVA DIPEGAVDKT ARVIELIDAY RTRGHLMADT 430 440 450 460 470 480 DPLNYRQRKH QDLDVLSHGL TLWDLDREFP VGGFAGKERM RLRDILGVLR NSYCRTVGVE 490 500 510 520 530 540 YMHILDPEER LWIQERVEVP HEKPPATVQK YILSKLNAAE AFETFLQTKY VGQKRFSLEG 550 560 570 580 590 600 GETVIPLLDA VLDKAAEHEL DEVVIGMPHR GRLNVLANIV GKPISQIFRE FEGNLDPGQA 610 620 630 640 650 660 HGSGDVKYHL GAEGKYFRMF GDGETKVSLT ANPSHLEAVD PVLEGIVRAK QDILDMGGES 670 680 690 700 710 720 FPVLPVAMHG DAAFAGQGVV AETLNLALVR GYRTGGTVHV IVNNQVGFTT APENSRSSKY 730 740 750 760 770 780 STDVAKMIGA PVFHVNGDDP EACYWVAKLA VDYRQAFNKD VVIDMVCYRR RGHNEGDDPS 790 800 810 820 830 840 MTQPAMYDVI DTKRSVRKTY TEALIGRGDI SVEEAEKALQ DFSSQLEHVF NEVRELEKHP 850 860 870 880 890 900 IKASPSVEEE QQVPAKLPTG VPREVLERIA DAHVELPEGF TPHPRVKPVL ERRAKMAREG 910 920 930 940 950 960 GIDWAYAELL AFGSLVHEGR TVRLAGQDSR RGTFTQRHAT LIDRKTGQEY TPIQNLADDQ 970 980 990 1000 1010 1020 GKFMVYDSVL SEFAALGFEY GYSVANPDAL VLWEAQFGDF VNGAQPIIDE FISSGEAKWG 1030 1040 1050 1060 1070 1080 QVSDVVLLLP HGHEGQGPDH TSGRIERFLQ LCAEGSMTIA VPSTPANYFH LLRRHALDGV 1090 1100 1110 1120 1130 1140 NRPLVVFTPK SMLRLKAAVS PVEDFVEERF KSVIDDAAIE DNSAVTKVLL CSGKIYYELV 1150 1160 1170 1180 1190 1200 AEREKRGAKD TAIVRVEQLY PVPKRKLNEA LEAYPNANDV RWVQEEPANQ GAWTFYGLHL 1210 1220 1230 1240 PELLPERYRL TRVSRRRMAA PSAGSSKVHE VEQREIITKA FE

References

[1]

"Complete genome sequence of Actinosynnema mirum type strain (101)." Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Glavina del Rio T., Nolan M., Lucas S., Tice H., Cheng J.-F., Chertkov O., Bruce D., Goodwin L., Pitluck S., Rohde M., Goeker M., Pati A., Ivanova N. , Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.-J., Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.-P. Stand. Genomic Sci. 1:46-53(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001630 Genomic DNA. Translation: ACU40057.1.
RefSeq	YP_003103903.1. NC_013093.1.
3D structure databases
ProteinModelPortal	C6WIY1.
ModBase	Search...
Protein-protein interaction databases
STRING	C6WIY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8330464.
GenomeReviews	Gene locus Amir_6253 in contig CP001630_GR.
KEGG	ami:Amir_6253.
PATRIC	20775709. VBIActMir80567_6461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EGDEPAF.
ProtClustDB	PRK12270.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K01616.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6WIY1_ACTMD

Accession

Primary (citable) accession number: C6WIY1

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)