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Protein

D-alanine--D-alanine ligase

Gene

Amir_4256

Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMIR446462:G1GEY-4325-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Amir_4256Imported
OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
Taxonomic identifieri446462 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeActinosynnema
Proteomesi
  • UP000002213 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi446462.Amir_4256

Structurei

3D structure databases

ProteinModelPortaliC6WIM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 333ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108K06 Bacteria
COG1181 LUCA
HOGENOMiHOG000054607
KOiK01921
OMAiWFLEAGL
OrthoDBiPOG091H16YJ

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR011095 Dala_Dala_lig_C
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

C6WIM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVLHLTGS PVSPFFAELS TVYGRGCLGA AADPARYEFL VAHVTPDGRW
60 70 80 90 100
RFPADLTPEA LAAAPRLGLP EALGLIESRS VDVAVPQLFC PPGMTTYRAL
110 120 130 140 150
LDALGVPYPG NPPDVMALGA DKAMTRAVVA AAGVPVPEGR VVTSADPCPL
160 170 180 190 200
PPPFVVKPVD ADNSDGLTLV HDRADYHAAL DAAFACSPRR RALVERYVPP
210 220 230 240 250
GREVRCGVLV RSGVPTPLPL EEYPLPSGVR PRADKLADDG GGSLSLVAKA
260 270 280 290 300
DGRSWIVDHD DPVTAAVQEQ ALRCHEALGC RDYSLFDFRI DPEGRPWFLE
310 320 330
AGLYCSFAPT SVITTMAGAA GIGLAELFAE AVTTAARRG
Length:339
Mass (Da):35,841
Last modified:September 22, 2009 - v1
Checksum:i75B5758039D64E35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001630 Genomic DNA Translation: ACU38111.1
RefSeqiWP_015802998.1, NC_013093.1

Genome annotation databases

EnsemblBacteriaiACU38111; ACU38111; Amir_4256
KEGGiami:Amir_4256

Similar proteinsi

Entry informationi

Entry nameiC6WIM1_ACTMD
AccessioniPrimary (citable) accession number: C6WIM1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health