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C6WFA2

- C6WFA2_ACTMD

UniProt

C6WFA2 - C6WFA2_ACTMD

Protein

Kynureninase

Gene

kynU

Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei86 – 861Pyridoxal phosphateUniRule annotation
    Binding sitei179 – 1791Pyridoxal phosphateUniRule annotation
    Binding sitei182 – 1821Pyridoxal phosphateUniRule annotation
    Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
    Binding sitei234 – 2341Pyridoxal phosphateUniRule annotation
    Binding sitei260 – 2601Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAMIR446462:GH7R-279-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Amir_0265Imported
    OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
    Taxonomic identifieri446462 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeActinosynnema
    ProteomesiUP000002213: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi446462.Amir_0265.

    Structurei

    3D structure databases

    ProteinModelPortaliC6WFA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni112 – 1154Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiPKSIRTH.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6WFA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDPLAHVRE LFDLADDVVY LDGNSLGAPP RAVAERLDDV VRRQWGRRLI    50
    RSWSEGWWEA PQRVGDRIGR LVGAAPGQVV VGDSTSVNLF KALVGAVRGT 100
    DRSEIVVDAG TFPTDGYIAG SAAELTGLSL RPADPDDLRL DERTAVVLLN 150
    HVDYRTGRLL DMAGLTERAH EVGAKVVWDL CHSVGVLPIE LDALGVDLAV 200
    GCTYKFLNGG PGSPAFLYVP SAAQPGFRQP LTGWTGHREP FAMAAEYTPD 250
    AGIGRARAGT PDILSMLALD AALDVWDGVE LADVRAKGLA LTARFMELVR 300
    DLPGIEVITP ADGRRGHQVS LRHPEAARLM AELIAGGVIG DHRPPDVLRF 350
    GFAPLYNTFD EAERAAKALE ELL 373
    Length:373
    Mass (Da):40,159
    Last modified:September 22, 2009 - v1
    Checksum:iFAB9E82801C19316
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001630 Genomic DNA. Translation: ACU34234.1.
    RefSeqiWP_012782897.1. NC_013093.1.
    YP_003098080.1. NC_013093.1.

    Genome annotation databases

    EnsemblBacteriaiACU34234; ACU34234; Amir_0265.
    GeneIDi8324422.
    KEGGiami:Amir_0265.
    PATRICi20763285. VBIActMir80567_0270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001630 Genomic DNA. Translation: ACU34234.1 .
    RefSeqi WP_012782897.1. NC_013093.1.
    YP_003098080.1. NC_013093.1.

    3D structure databases

    ProteinModelPortali C6WFA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 446462.Amir_0265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU34234 ; ACU34234 ; Amir_0265 .
    GeneIDi 8324422.
    KEGGi ami:Amir_0265.
    PATRICi 20763285. VBIActMir80567_0270.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi PKSIRTH.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci AMIR446462:GH7R-279-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971Imported.

    Entry informationi

    Entry nameiC6WFA2_ACTMD
    AccessioniPrimary (citable) accession number: C6WFA2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3