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C6WFA2 (C6WFA2_ACTMD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. HAMAP-Rule MF_01970

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. HAMAP-Rule MF_01970

L-kynurenine + H2O = anthranilate + L-alanine. HAMAP-Rule MF_01970

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01970

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. HAMAP-Rule MF_01970

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. HAMAP-Rule MF_01970

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01970

Sequence similarities

Belongs to the kynureninase family. HAMAP-Rule MF_01970

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region112 – 1154Pyridoxal phosphate binding By similarity HAMAP-Rule MF_01970

Sites

Binding site851Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_01970
Binding site861Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site1791Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site1821Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2041Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2341Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2601Pyridoxal phosphate By similarity HAMAP-Rule MF_01970

Amino acid modifications

Modified residue2051N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01970

Sequences

Sequence LengthMass (Da)Tools
C6WFA2 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: FAB9E82801C19316

FASTA37340,159
        10         20         30         40         50         60 
MTDPLAHVRE LFDLADDVVY LDGNSLGAPP RAVAERLDDV VRRQWGRRLI RSWSEGWWEA 

        70         80         90        100        110        120 
PQRVGDRIGR LVGAAPGQVV VGDSTSVNLF KALVGAVRGT DRSEIVVDAG TFPTDGYIAG 

       130        140        150        160        170        180 
SAAELTGLSL RPADPDDLRL DERTAVVLLN HVDYRTGRLL DMAGLTERAH EVGAKVVWDL 

       190        200        210        220        230        240 
CHSVGVLPIE LDALGVDLAV GCTYKFLNGG PGSPAFLYVP SAAQPGFRQP LTGWTGHREP 

       250        260        270        280        290        300 
FAMAAEYTPD AGIGRARAGT PDILSMLALD AALDVWDGVE LADVRAKGLA LTARFMELVR 

       310        320        330        340        350        360 
DLPGIEVITP ADGRRGHQVS LRHPEAARLM AELIAGGVIG DHRPPDVLRF GFAPLYNTFD 

       370 
EAERAAKALE ELL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001630 Genomic DNA. Translation: ACU34234.1.
RefSeqYP_003098080.1. NC_013093.1.

3D structure databases

ProteinModelPortalC6WFA2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING446462.Amir_0265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU34234; ACU34234; Amir_0265.
GeneID8324422.
KEGGami:Amir_0265.
PATRIC20763285. VBIActMir80567_0270.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAPKSIRTH.
OrthoDBEOG6N67XP.

Enzyme and pathway databases

BioCycAMIR446462:GH7R-279-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6WFA2_ACTMD
AccessionPrimary (citable) accession number: C6WFA2
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)