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Protein

Xylose isomerase

Gene

xylA

Organism
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471UniRule annotation
Active sitei50 – 501UniRule annotation
Metal bindingi174 – 1741Magnesium 1UniRule annotation
Metal bindingi210 – 2101Magnesium 1UniRule annotation
Metal bindingi210 – 2101Magnesium 2UniRule annotation
Metal bindingi213 – 2131Magnesium 2UniRule annotation
Metal bindingi238 – 2381Magnesium 1UniRule annotation
Metal bindingi248 – 2481Magnesium 2UniRule annotation
Metal bindingi250 – 2501Magnesium 2UniRule annotation
Metal bindingi280 – 2801Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-1836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Amir_1795Imported
OrganismiActinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)Imported
Taxonomic identifieri446462 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeActinosynnema
ProteomesiUP000002213 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi446462.Amir_1795.

Structurei

3D structure databases

ProteinModelPortaliC6WCX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6WCX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFSFGLWT VGWQGRDPFG DATRPVLDAP TAVRKLAELG AWGVTFHDDD
60 70 80 90 100
LIPFGAGAAE RDRRVSAFRG ALDETGLVVP MVTTNLFTHP VFKDGGFTSN
110 120 130 140 150
DRSVRRFALR KVLRNLELAA ELGAKTIVLW GGREGSETDA GKDVQAALER
160 170 180 190 200
YREALDTVAQ HSVDQGYGFR FALEPKPNEP RGDILLPTVG HALAFISTLQ
210 220 230 240 250
HHELVGVNPE VGHEQMANLN FVHGIAQALW QKKLFHIDLN GQKGPRFDQD
260 270 280 290 300
LVFGHGDLLS AFFLVDLLEN GGYDGPRHFD YKPLRTEDVD GVWDSAAANM
310 320 330 340 350
RTYTLLKERA QAYRADPEVQ EALRVSGVTE QAVPTLGEGE SIADFLAADE
360 370
SFDPDKAAER GYGFVKLSQL ALEHLLGAR
Length:379
Mass (Da):41,711
Last modified:September 22, 2009 - v1
Checksum:iFDF9C447C8617C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001630 Genomic DNA. Translation: ACU35743.1.
RefSeqiWP_015800632.1. NC_013093.1.
YP_003099589.1. NC_013093.1.

Genome annotation databases

EnsemblBacteriaiACU35743; ACU35743; Amir_1795.
KEGGiami:Amir_1795.
PATRICi20766471. VBIActMir80567_1848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001630 Genomic DNA. Translation: ACU35743.1.
RefSeqiWP_015800632.1. NC_013093.1.
YP_003099589.1. NC_013093.1.

3D structure databases

ProteinModelPortaliC6WCX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi446462.Amir_1795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU35743; ACU35743; Amir_1795.
KEGGiami:Amir_1795.
PATRICi20766471. VBIActMir80567_1848.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciAMIR446462:GH7R-1836-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971Imported.

Entry informationi

Entry nameiC6WCX6_ACTMD
AccessioniPrimary (citable) accession number: C6WCX6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.