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Protein

Xylose isomerase

Gene

xylA

Organism
Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071UniRule annotation
Active sitei110 – 1101UniRule annotation
Metal bindingi238 – 2381Magnesium 1UniRule annotation
Metal bindingi274 – 2741Magnesium 1UniRule annotation
Metal bindingi274 – 2741Magnesium 2UniRule annotation
Metal bindingi277 – 2771Magnesium 2UniRule annotation
Metal bindingi302 – 3021Magnesium 1UniRule annotation
Metal bindingi313 – 3131Magnesium 2UniRule annotation
Metal bindingi315 – 3151Magnesium 2UniRule annotation
Metal bindingi345 – 3451Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciDFER471854:GI24-4765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Dfer_4723Imported
OrganismiDyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)Imported
Taxonomic identifieri471854 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeDyadobacter
ProteomesiUP000002011: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi471854.Dfer_4723.

Structurei

3D structure databases

ProteinModelPortaliC6W4V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6W4V0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILLGEQEY FKGIGKISFE GPETDNPLAY RWYDENRVIA GKTMKDHLRF
60 70 80 90 100
AVAYWHTFCG AGLDPFGGPT LFYPWDKKAD AVDRAKDKAD AAFEFITKLG
110 120 130 140 150
LPYYCFHDVD VVDYDDDVRT NEKRLQALTA YLGEKQKASG VKLLWGTANL
160 170 180 190 200
FGHHRYMNGA STNPDFDVVA HAGAQIKMAL DATIALGGEN YVFWGGREGY
210 220 230 240 250
MSLLNTDMKR EQEHFAQMLK ISVAYARANG FKGKFFIEPK PCEPTKHQYD
260 270 280 290 300
YDAATVIGFL RQHDLLADFS LNLEVNHATL AGHTFEHELQ VAADAGILGS
310 320 330 340 350
IDANRGDYQN GWDTDQFPND IAEWTRALLV ILNAGGLQGG GINFDAKRRR
360 370 380 390 400
NSTDVDDVFH AHIGGIDTVA RALVIADKII QNGAYDEIRK NRYASFDGGK
410 420 430 440
GADFEKGALK LEDLFELAAT KGEPATTSGK QEYLENLINR FL
Length:442
Mass (Da):49,255
Last modified:September 22, 2009 - v1
Checksum:iC52FBDAE999C4DEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95924.1.
RefSeqiWP_015814165.1. NC_013037.1.
YP_003089089.1. NC_013037.1.

Genome annotation databases

EnsemblBacteriaiACT95924; ACT95924; Dfer_4723.
GeneIDi8228329.
KEGGidfe:Dfer_4723.
PATRICi21831065. VBIDyaFer416_4851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95924.1.
RefSeqiWP_015814165.1. NC_013037.1.
YP_003089089.1. NC_013037.1.

3D structure databases

ProteinModelPortaliC6W4V0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471854.Dfer_4723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT95924; ACT95924; Dfer_4723.
GeneIDi8228329.
KEGGidfe:Dfer_4723.
PATRICi21831065. VBIDyaFer416_4851.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciDFER471854:GI24-4765-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700827 / DSM 18053 / NS114Imported.

Entry informationi

Entry nameiC6W4V0_DYAFD
AccessioniPrimary (citable) accession number: C6W4V0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.